Pertussis toxin promotes relapsing–remitting experimental autoimmune encephalomyelitis in Lewis rats

Abstract Animal models simulate different aspects of human diseases and are essential to get a better understanding of the disease, studying treatments and producing new drugs. Experimental autoimmune encephalomyelitis (EAE) is a preferred model in multiple sclerosis research. Common EAE model in Le...

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Veröffentlicht in:	Journal of neuroimmunology 2015-12, Vol.289, p.105-110
Hauptverfasser:	Mohajeri, Maryam, Sadeghizadeh, Majid, Javan, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Disease Models, Animal Disease Progression EAE Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - immunology Female Freund's Adjuvant - toxicity Gene Expression Regulation - drug effects Guinea Pigs Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Inflammation Inflammation - chemically induced Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - chemically induced Neurology NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Pertussis toxin Pertussis Toxin - toxicity Rats Rats, Inbred Lew Relapsing–remitting MS RNA, Messenger - metabolism Spinal Cord - immunology
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