Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent

Background Thymic stromal lymphopoietin (TSLP) released after antigenic stimulation of allergic asthmatic airways is a key initiator of type 2 inflammation. Basophils are important effectors of allergic inflammation in the airways. Murine basophils have been shown to respond to TSLP independently of...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2015-12, Vol.136 (6), p.1636-1644
Hauptverfasser:	Salter, Brittany M., BSc, Oliveria, John Paul, BSc, Nusca, Graeme, BSc, Smith, Steve G., PhD, Watson, Rick M., BSc, Comeau, Micheal, BSc, Sehmi, Roma, PhD, Gauvreau, Gail M., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adult Airway management Allergens - administration & dosage allergic asthma Allergies Allergy and Immunology Asthma Asthma - blood Asthma - immunology Asthma - physiopathology Basophils Basophils - immunology Bone marrow Bone Marrow Cells - immunology Bronchial Provocation Tests CD203c Cell Count Cells, Cultured Cytokines Cytokines - blood Cytokines - immunology epithelium-derived cytokines Female Flow cytometry Forced Expiratory Volume Humans Inflammation Male Middle Aged Sputum - cytology Sputum - immunology Studies TH2 cytokines thymic stromal lymphopoietin Young Adult
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