The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers

Abstract An increasing number of evidence showed that genetic factors might contribute to drug abuse vulnerability. Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependenc...

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Veröffentlicht in:Comprehensive psychiatry 2015-05, Vol.59, p.62-67
Hauptverfasser: Su, Hang, Tao, Jingyan, Zhang, Jie, Xie, Ying, Han, Bin, Lu, Yuling, Sun, Haiwei, Wei, Youdan, Wang, Yue, Zhang, Yu, Zou, Shengzhen, Wu, Wenxiu, Zhang, Jiajia, Xu, Ke, Zhang, Xiangyang, He, Jincai
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container_issue
container_start_page 62
container_title Comprehensive psychiatry
container_volume 59
creator Su, Hang
Tao, Jingyan
Zhang, Jie
Xie, Ying
Han, Bin
Lu, Yuling
Sun, Haiwei
Wei, Youdan
Wang, Yue
Zhang, Yu
Zou, Shengzhen
Wu, Wenxiu
Zhang, Jiajia
Xu, Ke
Zhang, Xiangyang
He, Jincai
description Abstract An increasing number of evidence showed that genetic factors might contribute to drug abuse vulnerability. Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependence. To test the hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy individuals. We also considered the association of these polymorphisms with impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) Chinese version. Individual SNP analysis showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Haplotype analysis of rs16917204–rs16917234–rs2030324 revealed that a major C–C–T haplotype was significantly associated a lower odds of methamphetamine abuse, even after Bonferroni correction. Within the methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype had significantly higher motor impulsivity scores of BIS compared to those with the C/C genotype. Our findings suggest that the BDNF gene polymorphism may contribute to the impulsivity in methamphetamine abusers.
doi_str_mv 10.1016/j.comppsych.2015.02.017
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Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependence. To test the hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy individuals. We also considered the association of these polymorphisms with impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) Chinese version. Individual SNP analysis showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Haplotype analysis of rs16917204–rs16917234–rs2030324 revealed that a major C–C–T haplotype was significantly associated a lower odds of methamphetamine abuse, even after Bonferroni correction. Within the methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype had significantly higher motor impulsivity scores of BIS compared to those with the C/C genotype. 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Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependence. To test the hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy individuals. We also considered the association of these polymorphisms with impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) Chinese version. Individual SNP analysis showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Haplotype analysis of rs16917204–rs16917234–rs2030324 revealed that a major C–C–T haplotype was significantly associated a lower odds of methamphetamine abuse, even after Bonferroni correction. Within the methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype had significantly higher motor impulsivity scores of BIS compared to those with the C/C genotype. 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Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependence. To test the hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy individuals. We also considered the association of these polymorphisms with impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) Chinese version. Individual SNP analysis showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Haplotype analysis of rs16917204–rs16917234–rs2030324 revealed that a major C–C–T haplotype was significantly associated a lower odds of methamphetamine abuse, even after Bonferroni correction. Within the methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype had significantly higher motor impulsivity scores of BIS compared to those with the C/C genotype. Our findings suggest that the BDNF gene polymorphism may contribute to the impulsivity in methamphetamine abusers.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25764907</pmid><doi>10.1016/j.comppsych.2015.02.017</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Addictive behaviors
Alleles
Amphetamine-Related Disorders - genetics
Amphetamine-Related Disorders - psychology
Asian Continental Ancestry Group - genetics
Attention deficit hyperactivity disorder
Behavior
Bipolar disorder
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Case-Control Studies
Drug use
Genes
Genetic Predisposition to Disease - genetics
Genotype
Haplotypes - genetics
Humans
Hyperactivity
Impulsive Behavior
Impulsivity
Methamphetamine
Narcotics
Polymorphism, Single Nucleotide - genetics
Psychiatry
Studies
title The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers
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