The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers
Abstract An increasing number of evidence showed that genetic factors might contribute to drug abuse vulnerability. Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependenc...
Gespeichert in:
Veröffentlicht in: | Comprehensive psychiatry 2015-05, Vol.59, p.62-67 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 67 |
---|---|
container_issue | |
container_start_page | 62 |
container_title | Comprehensive psychiatry |
container_volume | 59 |
creator | Su, Hang Tao, Jingyan Zhang, Jie Xie, Ying Han, Bin Lu, Yuling Sun, Haiwei Wei, Youdan Wang, Yue Zhang, Yu Zou, Shengzhen Wu, Wenxiu Zhang, Jiajia Xu, Ke Zhang, Xiangyang He, Jincai |
description | Abstract An increasing number of evidence showed that genetic factors might contribute to drug abuse vulnerability. Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependence. To test the hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy individuals. We also considered the association of these polymorphisms with impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) Chinese version. Individual SNP analysis showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Haplotype analysis of rs16917204–rs16917234–rs2030324 revealed that a major C–C–T haplotype was significantly associated a lower odds of methamphetamine abuse, even after Bonferroni correction. Within the methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype had significantly higher motor impulsivity scores of BIS compared to those with the C/C genotype. Our findings suggest that the BDNF gene polymorphism may contribute to the impulsivity in methamphetamine abusers. |
doi_str_mv | 10.1016/j.comppsych.2015.02.017 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1785229936</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0010440X15000334</els_id><sourcerecordid>3650626771</sourcerecordid><originalsourceid>FETCH-LOGICAL-c557t-5c16db7b83ad0ab8c324eb460fac5ca32c62ec8ea2f4d2499f910d349934b12a3</originalsourceid><addsrcrecordid>eNqNkk-L1TAUxYMoznP0K2jBjZvW_GuTtxHG0VFh0IUjuBBCmt7aPJsmJu1Av72pbxxhNrrKXfzOueSeg9AzgiuCSfPyUBnvQkirGSqKSV1hWmEi7qEdqRktJZP8PtphTHDJOf56gh6ldMAYSyn5Q3RCa9HwPRY79O1qgEJPelyTTYXvi9dvPl4U32GCIvhxdT6GwSZXDDqMfl4DpEx3hXVhGZO9tvNa2KlwMA_ahQFm7WyW6nZJENNj9KDXY4InN-8p-nLx9ur8fXn56d2H87PL0tS1mMvakKZrRSuZ7rBupWGUQ8sb3GtTG82oaSgYCZr2vKN8v-_3BHcsD4y3hGp2il4cfUP0PxdIs3I2GRhHPYFfkiJC1pRmvPk32gjGRCMbnNHnd9CDX2I-1W-KErKnYqPEkTLRpxShVyFap-OqCFZbVuqgbrNSW1YKU5WzysqnN_5L66C71f0JJwNnRwDy7a4tRJWMhclAZyOYWXXe_seSV3c8zGgna_T4A1ZIf3-kUhaoz1tltsaQOreFMc5-Ael2vxc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1672119270</pqid></control><display><type>article</type><title>The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>ProQuest Central UK/Ireland</source><creator>Su, Hang ; Tao, Jingyan ; Zhang, Jie ; Xie, Ying ; Han, Bin ; Lu, Yuling ; Sun, Haiwei ; Wei, Youdan ; Wang, Yue ; Zhang, Yu ; Zou, Shengzhen ; Wu, Wenxiu ; Zhang, Jiajia ; Xu, Ke ; Zhang, Xiangyang ; He, Jincai</creator><creatorcontrib>Su, Hang ; Tao, Jingyan ; Zhang, Jie ; Xie, Ying ; Han, Bin ; Lu, Yuling ; Sun, Haiwei ; Wei, Youdan ; Wang, Yue ; Zhang, Yu ; Zou, Shengzhen ; Wu, Wenxiu ; Zhang, Jiajia ; Xu, Ke ; Zhang, Xiangyang ; He, Jincai</creatorcontrib><description>Abstract An increasing number of evidence showed that genetic factors might contribute to drug abuse vulnerability. Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependence. To test the hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy individuals. We also considered the association of these polymorphisms with impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) Chinese version. Individual SNP analysis showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Haplotype analysis of rs16917204–rs16917234–rs2030324 revealed that a major C–C–T haplotype was significantly associated a lower odds of methamphetamine abuse, even after Bonferroni correction. Within the methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype had significantly higher motor impulsivity scores of BIS compared to those with the C/C genotype. Our findings suggest that the BDNF gene polymorphism may contribute to the impulsivity in methamphetamine abusers.</description><identifier>ISSN: 0010-440X</identifier><identifier>EISSN: 1532-8384</identifier><identifier>DOI: 10.1016/j.comppsych.2015.02.017</identifier><identifier>PMID: 25764907</identifier><identifier>CODEN: COPYAV</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Addictive behaviors ; Alleles ; Amphetamine-Related Disorders - genetics ; Amphetamine-Related Disorders - psychology ; Asian Continental Ancestry Group - genetics ; Attention deficit hyperactivity disorder ; Behavior ; Bipolar disorder ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; Case-Control Studies ; Drug use ; Genes ; Genetic Predisposition to Disease - genetics ; Genotype ; Haplotypes - genetics ; Humans ; Hyperactivity ; Impulsive Behavior ; Impulsivity ; Methamphetamine ; Narcotics ; Polymorphism, Single Nucleotide - genetics ; Psychiatry ; Studies</subject><ispartof>Comprehensive psychiatry, 2015-05, Vol.59, p.62-67</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited May 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-5c16db7b83ad0ab8c324eb460fac5ca32c62ec8ea2f4d2499f910d349934b12a3</citedby><cites>FETCH-LOGICAL-c557t-5c16db7b83ad0ab8c324eb460fac5ca32c62ec8ea2f4d2499f910d349934b12a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1672119270?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25764907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Hang</creatorcontrib><creatorcontrib>Tao, Jingyan</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Xie, Ying</creatorcontrib><creatorcontrib>Han, Bin</creatorcontrib><creatorcontrib>Lu, Yuling</creatorcontrib><creatorcontrib>Sun, Haiwei</creatorcontrib><creatorcontrib>Wei, Youdan</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Zou, Shengzhen</creatorcontrib><creatorcontrib>Wu, Wenxiu</creatorcontrib><creatorcontrib>Zhang, Jiajia</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><creatorcontrib>He, Jincai</creatorcontrib><title>The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers</title><title>Comprehensive psychiatry</title><addtitle>Compr Psychiatry</addtitle><description>Abstract An increasing number of evidence showed that genetic factors might contribute to drug abuse vulnerability. Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependence. To test the hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy individuals. We also considered the association of these polymorphisms with impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) Chinese version. Individual SNP analysis showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Haplotype analysis of rs16917204–rs16917234–rs2030324 revealed that a major C–C–T haplotype was significantly associated a lower odds of methamphetamine abuse, even after Bonferroni correction. Within the methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype had significantly higher motor impulsivity scores of BIS compared to those with the C/C genotype. Our findings suggest that the BDNF gene polymorphism may contribute to the impulsivity in methamphetamine abusers.</description><subject>Addictive behaviors</subject><subject>Alleles</subject><subject>Amphetamine-Related Disorders - genetics</subject><subject>Amphetamine-Related Disorders - psychology</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Behavior</subject><subject>Bipolar disorder</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Case-Control Studies</subject><subject>Drug use</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Impulsive Behavior</subject><subject>Impulsivity</subject><subject>Methamphetamine</subject><subject>Narcotics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychiatry</subject><subject>Studies</subject><issn>0010-440X</issn><issn>1532-8384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk-L1TAUxYMoznP0K2jBjZvW_GuTtxHG0VFh0IUjuBBCmt7aPJsmJu1Av72pbxxhNrrKXfzOueSeg9AzgiuCSfPyUBnvQkirGSqKSV1hWmEi7qEdqRktJZP8PtphTHDJOf56gh6ldMAYSyn5Q3RCa9HwPRY79O1qgEJPelyTTYXvi9dvPl4U32GCIvhxdT6GwSZXDDqMfl4DpEx3hXVhGZO9tvNa2KlwMA_ahQFm7WyW6nZJENNj9KDXY4InN-8p-nLx9ur8fXn56d2H87PL0tS1mMvakKZrRSuZ7rBupWGUQ8sb3GtTG82oaSgYCZr2vKN8v-_3BHcsD4y3hGp2il4cfUP0PxdIs3I2GRhHPYFfkiJC1pRmvPk32gjGRCMbnNHnd9CDX2I-1W-KErKnYqPEkTLRpxShVyFap-OqCFZbVuqgbrNSW1YKU5WzysqnN_5L66C71f0JJwNnRwDy7a4tRJWMhclAZyOYWXXe_seSV3c8zGgna_T4A1ZIf3-kUhaoz1tltsaQOreFMc5-Ael2vxc</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Su, Hang</creator><creator>Tao, Jingyan</creator><creator>Zhang, Jie</creator><creator>Xie, Ying</creator><creator>Han, Bin</creator><creator>Lu, Yuling</creator><creator>Sun, Haiwei</creator><creator>Wei, Youdan</creator><creator>Wang, Yue</creator><creator>Zhang, Yu</creator><creator>Zou, Shengzhen</creator><creator>Wu, Wenxiu</creator><creator>Zhang, Jiajia</creator><creator>Xu, Ke</creator><creator>Zhang, Xiangyang</creator><creator>He, Jincai</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20150501</creationdate><title>The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers</title><author>Su, Hang ; Tao, Jingyan ; Zhang, Jie ; Xie, Ying ; Han, Bin ; Lu, Yuling ; Sun, Haiwei ; Wei, Youdan ; Wang, Yue ; Zhang, Yu ; Zou, Shengzhen ; Wu, Wenxiu ; Zhang, Jiajia ; Xu, Ke ; Zhang, Xiangyang ; He, Jincai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-5c16db7b83ad0ab8c324eb460fac5ca32c62ec8ea2f4d2499f910d349934b12a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Addictive behaviors</topic><topic>Alleles</topic><topic>Amphetamine-Related Disorders - genetics</topic><topic>Amphetamine-Related Disorders - psychology</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Behavior</topic><topic>Bipolar disorder</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Case-Control Studies</topic><topic>Drug use</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Haplotypes - genetics</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Impulsive Behavior</topic><topic>Impulsivity</topic><topic>Methamphetamine</topic><topic>Narcotics</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychiatry</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Hang</creatorcontrib><creatorcontrib>Tao, Jingyan</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Xie, Ying</creatorcontrib><creatorcontrib>Han, Bin</creatorcontrib><creatorcontrib>Lu, Yuling</creatorcontrib><creatorcontrib>Sun, Haiwei</creatorcontrib><creatorcontrib>Wei, Youdan</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><creatorcontrib>Zou, Shengzhen</creatorcontrib><creatorcontrib>Wu, Wenxiu</creatorcontrib><creatorcontrib>Zhang, Jiajia</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><creatorcontrib>He, Jincai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Comprehensive psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Hang</au><au>Tao, Jingyan</au><au>Zhang, Jie</au><au>Xie, Ying</au><au>Han, Bin</au><au>Lu, Yuling</au><au>Sun, Haiwei</au><au>Wei, Youdan</au><au>Wang, Yue</au><au>Zhang, Yu</au><au>Zou, Shengzhen</au><au>Wu, Wenxiu</au><au>Zhang, Jiajia</au><au>Xu, Ke</au><au>Zhang, Xiangyang</au><au>He, Jincai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers</atitle><jtitle>Comprehensive psychiatry</jtitle><addtitle>Compr Psychiatry</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>59</volume><spage>62</spage><epage>67</epage><pages>62-67</pages><issn>0010-440X</issn><eissn>1532-8384</eissn><coden>COPYAV</coden><abstract>Abstract An increasing number of evidence showed that genetic factors might contribute to drug abuse vulnerability. Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependence. To test the hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy individuals. We also considered the association of these polymorphisms with impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) Chinese version. Individual SNP analysis showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Haplotype analysis of rs16917204–rs16917234–rs2030324 revealed that a major C–C–T haplotype was significantly associated a lower odds of methamphetamine abuse, even after Bonferroni correction. Within the methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype had significantly higher motor impulsivity scores of BIS compared to those with the C/C genotype. Our findings suggest that the BDNF gene polymorphism may contribute to the impulsivity in methamphetamine abusers.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25764907</pmid><doi>10.1016/j.comppsych.2015.02.017</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0010-440X |
ispartof | Comprehensive psychiatry, 2015-05, Vol.59, p.62-67 |
issn | 0010-440X 1532-8384 |
language | eng |
recordid | cdi_proquest_miscellaneous_1785229936 |
source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
subjects | Addictive behaviors Alleles Amphetamine-Related Disorders - genetics Amphetamine-Related Disorders - psychology Asian Continental Ancestry Group - genetics Attention deficit hyperactivity disorder Behavior Bipolar disorder Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Case-Control Studies Drug use Genes Genetic Predisposition to Disease - genetics Genotype Haplotypes - genetics Humans Hyperactivity Impulsive Behavior Impulsivity Methamphetamine Narcotics Polymorphism, Single Nucleotide - genetics Psychiatry Studies |
title | The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T21%3A06%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20analysis%20of%20BDNF%20gene%20polymorphism%20haplotypes%20and%20impulsivity%20in%20methamphetamine%20abusers&rft.jtitle=Comprehensive%20psychiatry&rft.au=Su,%20Hang&rft.date=2015-05-01&rft.volume=59&rft.spage=62&rft.epage=67&rft.pages=62-67&rft.issn=0010-440X&rft.eissn=1532-8384&rft.coden=COPYAV&rft_id=info:doi/10.1016/j.comppsych.2015.02.017&rft_dat=%3Cproquest_cross%3E3650626771%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1672119270&rft_id=info:pmid/25764907&rft_els_id=1_s2_0_S0010440X15000334&rfr_iscdi=true |