Involvement of NMDA receptors and l-arginine/nitric oxide/cyclic guanosine monophosphate pathway in the antidepressant-like effects of topiramate in mice forced swimming test

[Display omitted] •Topiramate (TPM) decreased the immobility time of mice in FST.•NMDA antagonists and NOS inhibitors potentiated the effect of TPM in FST.•NMDA receptor agonist and NO-precursor prevented the anti-immobility effect of TPM.•Sildenafil as PDE 5 inhibitor prevented the anti-immobility...

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Veröffentlicht in:	Brain research bulletin 2016-04, Vol.122, p.62-70
Hauptverfasser:	Ostadhadi, Sattar, Khan, Muhammad Imran, Norouzi-Javidan, Abbas, Chamanara, Mohsen, Jazaeri, Farahnaz, Zolfaghari, Samira, Dehpour, Ahmad-Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Arginine - metabolism Behavior, Animal - drug effects Cyclic GMP - metabolism Depression Depression - drug therapy Depression - metabolism Enzyme Inhibitors - pharmacology Forced swimming test Fructose - analogs & derivatives Fructose - pharmacology Hindlimb Suspension Male Mice Neurology Nitric oxide Nitric Oxide - metabolism NMDA Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction Swimming Topiramate
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