Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

Even small variations in dNTP concentrations decrease DNA replication fidelity, and this observation prompted us to analyze genomic cancer data formutations in enzymes involved in dNTP metabolism. We found that sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1), a deoxy...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-04, Vol.113 (17), p.4723-4728
Hauptverfasser:	Rentoft, Matilda, Lindell, Kristoffer, Tran, Phong, Chabes, Anna Lena, Buckland, Robert J., Watt, Danielle L., Marjavaara, Lisette, Nilsson, Anna Karin, Melin, Beatrice, Trygg, Johan, Johansson, Erik, Chabes, Andrei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell Line, Tumor cell research cellforskning Colonic Neoplasms - genetics Colorectal cancer Deoxyribonucleic acid Deoxyribonucleotides - genetics DNA DNA Replication DNA, Neoplasm - genetics Enzymes Genetic Predisposition to Disease - genetics Heterozygote Humans Inactivation Metabolism Mice Mice, Inbred C57BL Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Mutation Mutation - genetics Polymorphism, Single Nucleotide - genetics SAM Domain and HD Domain-Containing Protein 1 Tumors
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