Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling

Recently, it has been found that glucagon is able to activate the β-catenin signalling pathway leading to increased cyclin D1 and c-Myc expression in liver. Therefore the main aim of the present study is to determine whether the effect of glucagon activating β-catenin signalling leading to increased...

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Veröffentlicht in:	Biochemical journal 2016-05, Vol.473 (9), p.1247-1255
Hauptverfasser:	Chowdhury, Md Kamrul H, Wu, Lindsay E, Coleman, James L J, Smith, Nicola J, Morris, Margaret J, Shepherd, Peter R, Smith, Greg C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Bucladesine - pharmacology Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Glucagon - metabolism Hepatocytes - metabolism Male Niclosamide - pharmacology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Proto-Oncogene Proteins c-myc - metabolism Rats Rats, Sprague-Dawley Signal Transduction - drug effects
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