HNF-3 beta, C/EBP beta, and HNF-4 act in synergy to enhance transcription of the human apolipoprotein B gene in intestinal cells

Recently, we identified a 315-bp intestinal enhancer (IE), localized over 55 kb upstream from the transcriptional start of the human apolipoprotein B (apoB) gene, that confers expression of human apoB transgenes in the intestines of mice. Four functional binding sites for the intestine-enriched tran...

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Veröffentlicht in:	DNA and cell biology 2001-02, Vol.20 (2), p.67-74
Hauptverfasser:	Antes, T J, Levy-Wilson, B
Format:	Artikel
Sprache:	eng
Schlagworte:	apoB gene apolipoprotein B Apolipoproteins B - genetics Apolipoproteins B - metabolism Base Composition Basic Helix-Loop-Helix Leucine Zipper Transcription Factors C/EBP^b protein Caco-2 Cells CCAAT-Enhancer-Binding Protein-beta - metabolism CCAAT-Enhancer-Binding Protein-beta - physiology DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Drug Synergism Enhancer Elements, Genetic Hepatocyte Nuclear Factor 3-beta Hepatocyte Nuclear Factor 4 Hepatocytes - physiology HNF-3^b protein HNF-4 protein Humans Intestines - metabolism Mutagenesis, Site-Directed Nuclear Proteins - metabolism Nuclear Proteins - physiology Phosphoproteins - metabolism Phosphoproteins - physiology Protein Binding - genetics Transcription Factors - metabolism Transcription Factors - physiology Transcription, Genetic
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