The role of carbon monoxide and nitric oxide in hyperosmolality-induced atrial natriuretic peptide release by hypothalamus in vitro

We evaluated the participation of the nitrergic and carbon monoxide (CO) systems in the atrial natriuretic peptide (ANP) release induced by osmotic stimulation of the rat anterior and medial basal hypothalamus (BH) fragments in vitro. The increase in the medium osmolality (NaCl, 340 mOsm/kg H 2O) in...

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Veröffentlicht in:	Brain research 2004-07, Vol.1016 (1), p.33-39
Hauptverfasser:	Gomes, Dayane Aparecida, Reis, Wagner Luiz, Ventura, Renato Rizo, Giusti-Paiva, Alexandre, Elias, Lucila Leico Kagohara, Cunha, Fernando Queiroz, Antunes-Rodrigues, Jose
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals ANP Atrial Natriuretic Factor - metabolism Biochemistry and metabolism Biological and medical sciences Carbon monoxide Carbon Monoxide - physiology Central nervous system Citrulline - metabolism Dose-Response Relationship, Drug Drug Interactions Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hemoglobins - pharmacology Hyperosmolality Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism In Vitro Techniques Male NG-Nitroarginine Methyl Ester - pharmacology Nitrates - metabolism Nitric oxide Nitric Oxide - physiology Nitric Oxide Donors - pharmacology omega-N-Methylarginine - pharmacology Osmolar Concentration Potassium Chloride - pharmacology Rats Vertebrates: nervous system and sense organs
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Zusammenfassung:	We evaluated the participation of the nitrergic and carbon monoxide (CO) systems in the atrial natriuretic peptide (ANP) release induced by osmotic stimulation of the rat anterior and medial basal hypothalamus (BH) fragments in vitro. The increase in the medium osmolality (NaCl, 340 mOsm/kg H 2O) induced an elevated ANP release, which was associated with a decrease in nitric oxide synthase (NOS) activity ( p
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2004.04.047