Cytotoxic lesions of the hippocampus increase social investigation but do not impair social-recognition memory
A number of studies have implicated the hippocampal formation in social-recognition memory in the rat. The present study addressed this issue directly by assessing the effects of cytotoxic lesions confined to the hippocampus proper, encompassing the four CA subfields and the dentate gyrus, on this b...
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| Veröffentlicht in: | Experimental brain research 2001-05, Vol.138 (1), p.100-109 |
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| creator | BANNERMAN, D. M LEMAIRE, M BEGGS, S RAWLINS, J. N. P IVERSEN, S. D |
| description | A number of studies have implicated the hippocampal formation in social-recognition memory in the rat. The present study addressed this issue directly by assessing the effects of cytotoxic lesions confined to the hippocampus proper, encompassing the four CA subfields and the dentate gyrus, on this behavioural task. Ibotenate-induced hippocampal lesions led to locomotor hyperactivity and a marked spatial working-memory impairment on the elevated T-maze. In addition, they also led to increased social investigation. However, despite these clear effects, there was no effect of the lesions on social-recognition memory. These results suggest that the hippocampus proper does not subserve social-recognition memory; but does not, however, preclude the possibility that other areas of the hippocampal formation (e.g. entorhinal cortex or subiculum) may support this memory process. |
| doi_str_mv | 10.1007/s002210100687 |
| format | Article |
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M ; LEMAIRE, M ; BEGGS, S ; RAWLINS, J. N. P ; IVERSEN, S. D</creator><creatorcontrib>BANNERMAN, D. M ; LEMAIRE, M ; BEGGS, S ; RAWLINS, J. N. P ; IVERSEN, S. D</creatorcontrib><description>A number of studies have implicated the hippocampal formation in social-recognition memory in the rat. The present study addressed this issue directly by assessing the effects of cytotoxic lesions confined to the hippocampus proper, encompassing the four CA subfields and the dentate gyrus, on this behavioural task. Ibotenate-induced hippocampal lesions led to locomotor hyperactivity and a marked spatial working-memory impairment on the elevated T-maze. In addition, they also led to increased social investigation. However, despite these clear effects, there was no effect of the lesions on social-recognition memory. These results suggest that the hippocampus proper does not subserve social-recognition memory; but does not, however, preclude the possibility that other areas of the hippocampal formation (e.g. entorhinal cortex or subiculum) may support this memory process.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s002210100687</identifier><identifier>PMID: 11374076</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Anatomical correlates of behavior ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Brain Mapping ; Cortex (entorhinal) ; Cytotoxicity ; Dentate gyrus ; Excitatory Amino Acid Agonists - toxicity ; Fundamental and applied biological sciences. 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M</creatorcontrib><creatorcontrib>LEMAIRE, M</creatorcontrib><creatorcontrib>BEGGS, S</creatorcontrib><creatorcontrib>RAWLINS, J. N. P</creatorcontrib><creatorcontrib>IVERSEN, S. D</creatorcontrib><title>Cytotoxic lesions of the hippocampus increase social investigation but do not impair social-recognition memory</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>A number of studies have implicated the hippocampal formation in social-recognition memory in the rat. The present study addressed this issue directly by assessing the effects of cytotoxic lesions confined to the hippocampus proper, encompassing the four CA subfields and the dentate gyrus, on this behavioural task. Ibotenate-induced hippocampal lesions led to locomotor hyperactivity and a marked spatial working-memory impairment on the elevated T-maze. In addition, they also led to increased social investigation. However, despite these clear effects, there was no effect of the lesions on social-recognition memory. These results suggest that the hippocampus proper does not subserve social-recognition memory; but does not, however, preclude the possibility that other areas of the hippocampal formation (e.g. entorhinal cortex or subiculum) may support this memory process.</description><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Cortex (entorhinal)</subject><subject>Cytotoxicity</subject><subject>Dentate gyrus</subject><subject>Excitatory Amino Acid Agonists - toxicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - physiology</subject><subject>Hyperactivity</subject><subject>ibotenic acid</subject><subject>Ibotenic Acid - toxicity</subject><subject>Lesions</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Motor Activity - physiology</subject><subject>Odorants</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Recognition (Psychology) - physiology</subject><subject>Short term memory</subject><subject>Smell - physiology</subject><subject>Social Behavior</subject><subject>Social interactions</subject><subject>Space Perception - physiology</subject><subject>Spatial memory</subject><subject>Subiculum</subject><subject>Time Factors</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0VFr3DAMAGBTVnq3ax_3Ogwre0srxY6dPI5j3QoHfWmfg6NzWh9JnNnJ2P37um1gW58kwSchJMY-IVwhgL6OAHmOkHJV6hO2RinyDBHUB7YGQJnJEqsV-xjj4aUUGs7YClFoCVqt2bA9Tn7yfxzxzkbnh8h9y6cny5_cOHoy_ThH7gYK1kTLoydnulT_tnFyj2ZKHbyZJ773fPATd_1oXFhYFiz5x8G9ot72PhzP2WlrumgvlrhhDzff77c_s93dj9vtt11GQusp0w2JvC0FkcCmsi20YHRRSElVpRRSKQpoGjKkhNJir43WFhtZNMUeVGoRG_b1be4Y_K857Vr3LpLtOjNYP8cadSkrQJXgl3fw4OcwpN3qXKPGspKqSCp7UxR8jMG29Rhcb8KxRqhf3lD_94bkPy9T56a3-796uXsClwswkUzXBjOQi_84wEpW4hkf2JAS</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>BANNERMAN, D. 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M</au><au>LEMAIRE, M</au><au>BEGGS, S</au><au>RAWLINS, J. N. P</au><au>IVERSEN, S. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic lesions of the hippocampus increase social investigation but do not impair social-recognition memory</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>138</volume><issue>1</issue><spage>100</spage><epage>109</epage><pages>100-109</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>A number of studies have implicated the hippocampal formation in social-recognition memory in the rat. The present study addressed this issue directly by assessing the effects of cytotoxic lesions confined to the hippocampus proper, encompassing the four CA subfields and the dentate gyrus, on this behavioural task. 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| subjects | Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences Brain Mapping Cortex (entorhinal) Cytotoxicity Dentate gyrus Excitatory Amino Acid Agonists - toxicity Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiology Hyperactivity ibotenic acid Ibotenic Acid - toxicity Lesions Male Maze Learning - physiology Motor Activity - physiology Odorants Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred Strains Recognition (Psychology) - physiology Short term memory Smell - physiology Social Behavior Social interactions Space Perception - physiology Spatial memory Subiculum Time Factors |
| title | Cytotoxic lesions of the hippocampus increase social investigation but do not impair social-recognition memory |
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