Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?
It is well known that leptin, the ob gene product, is involved in the regulation of food intake and thermogenesis. Recent studies also demonstrate that leptin may be able to modulate functions of cells involved in nonspecific immune response such as phagocytosis and secretion of cytokines by macroph...
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| Veröffentlicht in: | Journal of leukocyte biology 2001-03, Vol.69 (3), p.414-418 |
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| container_end_page | 418 |
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| container_title | Journal of leukocyte biology |
| container_volume | 69 |
| creator | Caldefie‐Chezet, F. Poulin, A. Tridon, A. Sion, B. Vasson, M‐P. |
| description | It is well known that leptin, the ob gene product, is involved in the regulation of food intake and thermogenesis. Recent studies also demonstrate that leptin may be able to modulate functions of cells involved in nonspecific immune response such as phagocytosis and secretion of cytokines by macrophages. This and the prominent implication of polymorphonuclear neutrophils (PMNs) in infectious response suggested a possible role of leptin as a modulator of PMN functions. We detected a leptin receptor on the PMN membrane by immunocytochemistry with an anti‐leptin receptor. Using chemiluminescence we then demonstrated that leptin enhances oxidative species production by stimulated PMNs. These results show for the first time that a functional leptin receptor is present on PMNs and that leptin may be able to influence their oxidative capacity. |
| doi_str_mv | 10.1189/jlb.69.3.414 |
| format | Article |
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Recent studies also demonstrate that leptin may be able to modulate functions of cells involved in nonspecific immune response such as phagocytosis and secretion of cytokines by macrophages. This and the prominent implication of polymorphonuclear neutrophils (PMNs) in infectious response suggested a possible role of leptin as a modulator of PMN functions. We detected a leptin receptor on the PMN membrane by immunocytochemistry with an anti‐leptin receptor. Using chemiluminescence we then demonstrated that leptin enhances oxidative species production by stimulated PMNs. 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Recent studies also demonstrate that leptin may be able to modulate functions of cells involved in nonspecific immune response such as phagocytosis and secretion of cytokines by macrophages. This and the prominent implication of polymorphonuclear neutrophils (PMNs) in infectious response suggested a possible role of leptin as a modulator of PMN functions. We detected a leptin receptor on the PMN membrane by immunocytochemistry with an anti‐leptin receptor. Using chemiluminescence we then demonstrated that leptin enhances oxidative species production by stimulated PMNs. These results show for the first time that a functional leptin receptor is present on PMNs and that leptin may be able to influence their oxidative capacity.</description><subject>bactericide</subject><subject>Blood Bactericidal Activity - immunology</subject><subject>Carrier Proteins - biosynthesis</subject><subject>Carrier Proteins - physiology</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leptin - immunology</subject><subject>Leptin - pharmacology</subject><subject>Luminescent Measurements</subject><subject>Lymphocytes - metabolism</subject><subject>Neutrophil Activation - drug effects</subject><subject>Neutrophil Activation - immunology</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>reactive oxygen species</subject><subject>receptor</subject><subject>Receptors, Cell Surface</subject><subject>Receptors, Leptin</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1r3DAQxUVJ6G6T3noOvqSnejP6WFnqJbShzQcLgZCchdaWslpky5FszP73VfDS3nqaYfi995iH0BcMK4yFvNr77YrLFV0xzD6gJZZUlJRX9AQtoWK4XDOABfqU0h4AKOHwES0wJhxXQizR08b0g-u-F7row2C6wWlfRPM6ej2EWASbz_7QhtjvQjfW3uhYdGYcYuh3zhdbXQ8muto1WZZ3F7rrc3RqtU_m83GeoZffv55v7srN4-39zY9NWbM1Z6UkVlOJCeGssdwyYFXNGkKgqqAC2RiwGMAILQXe0grXjeCWWkbZWjaSEHqGvs6-fQxvo0mDal2qjfe6M2FMKj_IBMcig99msI4hpWis6qNrdTwoDOq9Q5U7VFwqqnKHGb84-o7b1jT_4GNpGcAzMDlvDv81Uw-bnzCbXs6anXvdTS4alVrtfY4gapqmv-F_AMwCiWM</recordid><startdate>200103</startdate><enddate>200103</enddate><creator>Caldefie‐Chezet, F.</creator><creator>Poulin, A.</creator><creator>Tridon, A.</creator><creator>Sion, B.</creator><creator>Vasson, M‐P.</creator><general>Society for Leukocyte Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200103</creationdate><title>Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?</title><author>Caldefie‐Chezet, F. ; 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Recent studies also demonstrate that leptin may be able to modulate functions of cells involved in nonspecific immune response such as phagocytosis and secretion of cytokines by macrophages. This and the prominent implication of polymorphonuclear neutrophils (PMNs) in infectious response suggested a possible role of leptin as a modulator of PMN functions. We detected a leptin receptor on the PMN membrane by immunocytochemistry with an anti‐leptin receptor. Using chemiluminescence we then demonstrated that leptin enhances oxidative species production by stimulated PMNs. These results show for the first time that a functional leptin receptor is present on PMNs and that leptin may be able to influence their oxidative capacity.</abstract><cop>United States</cop><pub>Society for Leukocyte Biology</pub><pmid>11261788</pmid><doi>10.1189/jlb.69.3.414</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of leukocyte biology, 2001-03, Vol.69 (3), p.414-418 |
| issn | 0741-5400 1938-3673 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | bactericide Blood Bactericidal Activity - immunology Carrier Proteins - biosynthesis Carrier Proteins - physiology Dose-Response Relationship, Immunologic Humans Immunohistochemistry Leptin - immunology Leptin - pharmacology Luminescent Measurements Lymphocytes - metabolism Neutrophil Activation - drug effects Neutrophil Activation - immunology Neutrophils - immunology Neutrophils - metabolism reactive oxygen species receptor Receptors, Cell Surface Receptors, Leptin Recombinant Proteins - pharmacology Tetradecanoylphorbol Acetate - pharmacology |
| title | Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? |
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