UV but not γ irradiation accelerates p53-induced apoptosis of teratocarcinoma cells by repressing MDM2 transcription

Induction of p53 by DNA damage results in apoptosis of teratocarcinoma cells, whereas MDM2, encoded by a p53-responsive gene, can reverse this phenotype by inhibiting p53 function. Here we report that UV (10 or 20 J/m2), but not gamma irradiation (7 or 10 Gy), caused a massive apoptosis of human ter...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-11, Vol.60 (21), p.6184-6188
Hauptverfasser:	XIAOYA ZENG, KELLER, David, LIN WU, HUA LU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Apoptosis - radiation effects Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell physiology DNA, Neoplasm - genetics DNA, Neoplasm - radiation effects Effects of physical and chemical agents Fundamental and applied biological sciences. Psychology Gamma Rays Gene Expression Regulation, Neoplastic - radiation effects Humans MDM2 gene Medical sciences Molecular and cellular biology Nuclear Proteins Physical agents Promoter Regions, Genetic - genetics Promoter Regions, Genetic - radiation effects Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-mdm2 Response Elements - radiation effects Teratocarcinoma - genetics Teratocarcinoma - metabolism Teratocarcinoma - pathology Transcription, Genetic - radiation effects Tumor Cells, Cultured - radiation effects Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - physiology Tumors Ultraviolet Rays
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