Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients’ survival
Cannabinoid receptors (CB1R and CB2R) constitute essential members of the endocannabinoid system (ECS) which participates in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. The present study aimed to assess the clinical sign...
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| Veröffentlicht in: | Tumor biology 2016-03, Vol.37 (3), p.3647-3656 |
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| creator | Theocharis, Stamatios Giaginis, Constantinos Alexandrou, Paraskevi Rodriguez, Jose Tasoulas, Jason Danas, Eugene Patsouris, Efstratios Klijanienko, Jerzy |
| description | Cannabinoid receptors (CB1R and CB2R) constitute essential members of the endocannabinoid system (ECS) which participates in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. The present study aimed to assess the clinical significance of CB1R and CB2R protein expression in mobile tongue squamous cell carcinoma (SCC). CB1R and CB2R expression was assessed immunohistochemically on 28 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics and overall and disease-free patients’ survival. CB1R, CB2R, and concomitant CB1R/CB2R expression was significantly increased in older compared to younger mobile tongue SCC patients (
p
= 0.0243,
p
= 0.0079, and
p
= 0.0366, respectively). Enhanced CB2R and concomitant CB1R/CB2R expression was significantly more frequently observed in female compared to male mobile tongue SCC patients (
p
= 0.0025 and
p
= 0.0016, respectively). Elevated CB2R expression was significantly more frequently observed in mobile tongue SCC patients presenting well-defined tumor shape compared to those with diffuse (
p
= 0.0430). Mobile tongue SCC patients presenting enhanced CB1R, CB2R, or concomitant CB1R/CB2R expression showed significantly longer overall (log-rank test,
p
= 0.004,
p
= 0.011,
p
= 0.018, respectively) and disease-free (log-rank test,
p
= 0.003,
p
= 0.007,
p
= 0.027, respectively) survival times compared to those with low expression. In multivariate analysis, CB1R was identified as an independent prognostic factor for disease-free patients’ survival (Cox-regression analysis,
p
= 0.032). The present study provides evidence that CB1R and CB2R may play a role in the pathophysiological aspects of the mobile tongue SCC and even each molecule may constitute a potential target for the development of novel anti-cancer drugs for this type of malignancy. |
| doi_str_mv | 10.1007/s13277-015-4182-8 |
| format | Article |
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p
= 0.0243,
p
= 0.0079, and
p
= 0.0366, respectively). Enhanced CB2R and concomitant CB1R/CB2R expression was significantly more frequently observed in female compared to male mobile tongue SCC patients (
p
= 0.0025 and
p
= 0.0016, respectively). Elevated CB2R expression was significantly more frequently observed in mobile tongue SCC patients presenting well-defined tumor shape compared to those with diffuse (
p
= 0.0430). Mobile tongue SCC patients presenting enhanced CB1R, CB2R, or concomitant CB1R/CB2R expression showed significantly longer overall (log-rank test,
p
= 0.004,
p
= 0.011,
p
= 0.018, respectively) and disease-free (log-rank test,
p
= 0.003,
p
= 0.007,
p
= 0.027, respectively) survival times compared to those with low expression. In multivariate analysis, CB1R was identified as an independent prognostic factor for disease-free patients’ survival (Cox-regression analysis,
p
= 0.032). The present study provides evidence that CB1R and CB2R may play a role in the pathophysiological aspects of the mobile tongue SCC and even each molecule may constitute a potential target for the development of novel anti-cancer drugs for this type of malignancy.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-015-4182-8</identifier><identifier>PMID: 26459312</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - biosynthesis ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Middle Aged ; Multivariate Analysis ; Oral cancer ; Original Article ; Outcome Assessment (Health Care) - methods ; Outcome Assessment (Health Care) - statistics & numerical data ; Pathology ; Prognosis ; Proportional Hazards Models ; Receptor, Cannabinoid, CB1 - biosynthesis ; Receptor, Cannabinoid, CB2 - biosynthesis ; Sex Factors ; Tongue Neoplasms - metabolism ; Tongue Neoplasms - pathology ; Tongue Neoplasms - surgery ; Tumors</subject><ispartof>Tumor biology, 2016-03, Vol.37 (3), p.3647-3656</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2015</rights><rights>International Society of Oncology and BioMarkers (ISOBM) 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-bfa405a704a04ee3c591a52f3a5e7f643b477d9f387db5a22a4f59a9a190a043</citedby><cites>FETCH-LOGICAL-c372t-bfa405a704a04ee3c591a52f3a5e7f643b477d9f387db5a22a4f59a9a190a043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-015-4182-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-015-4182-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26459312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Theocharis, Stamatios</creatorcontrib><creatorcontrib>Giaginis, Constantinos</creatorcontrib><creatorcontrib>Alexandrou, Paraskevi</creatorcontrib><creatorcontrib>Rodriguez, Jose</creatorcontrib><creatorcontrib>Tasoulas, Jason</creatorcontrib><creatorcontrib>Danas, Eugene</creatorcontrib><creatorcontrib>Patsouris, Efstratios</creatorcontrib><creatorcontrib>Klijanienko, Jerzy</creatorcontrib><title>Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients’ survival</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>Cannabinoid receptors (CB1R and CB2R) constitute essential members of the endocannabinoid system (ECS) which participates in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. The present study aimed to assess the clinical significance of CB1R and CB2R protein expression in mobile tongue squamous cell carcinoma (SCC). CB1R and CB2R expression was assessed immunohistochemically on 28 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics and overall and disease-free patients’ survival. CB1R, CB2R, and concomitant CB1R/CB2R expression was significantly increased in older compared to younger mobile tongue SCC patients (
p
= 0.0243,
p
= 0.0079, and
p
= 0.0366, respectively). Enhanced CB2R and concomitant CB1R/CB2R expression was significantly more frequently observed in female compared to male mobile tongue SCC patients (
p
= 0.0025 and
p
= 0.0016, respectively). Elevated CB2R expression was significantly more frequently observed in mobile tongue SCC patients presenting well-defined tumor shape compared to those with diffuse (
p
= 0.0430). Mobile tongue SCC patients presenting enhanced CB1R, CB2R, or concomitant CB1R/CB2R expression showed significantly longer overall (log-rank test,
p
= 0.004,
p
= 0.011,
p
= 0.018, respectively) and disease-free (log-rank test,
p
= 0.003,
p
= 0.007,
p
= 0.027, respectively) survival times compared to those with low expression. In multivariate analysis, CB1R was identified as an independent prognostic factor for disease-free patients’ survival (Cox-regression analysis,
p
= 0.032). The present study provides evidence that CB1R and CB2R may play a role in the pathophysiological aspects of the mobile tongue SCC and even each molecule may constitute a potential target for the development of novel anti-cancer drugs for this type of malignancy.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Oral cancer</subject><subject>Original Article</subject><subject>Outcome Assessment (Health Care) - methods</subject><subject>Outcome Assessment (Health Care) - statistics & numerical data</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Receptor, Cannabinoid, CB1 - biosynthesis</subject><subject>Receptor, Cannabinoid, CB2 - biosynthesis</subject><subject>Sex Factors</subject><subject>Tongue Neoplasms - metabolism</subject><subject>Tongue Neoplasms - pathology</subject><subject>Tongue Neoplasms - surgery</subject><subject>Tumors</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1u1EAQhS0EIiFwADaoJTbZGPp32mYHo_AjRWKTfavcU550ZHc7XXYCO66RS3AoTkKbCQghsaqS6qv3qvSq6rngrwTn9jUJJa2tuTC1Fo2smwfVsdBS1Vw1_GHpueC1lo06qp4QXfECtu3mcXUkN9q0Ssjj6vvZDQwLzCFFlnrmIUboQkxhx7bvBIO4VskyepzmlInhlykj0cqHyMbUhQHZnOJ-QUbXC4xpIeZxGIpW9kVphDcMiJIPv1yI3Yb5kvkhxODTBPNlGtI-eBjYBBlGnLG4rL5lFjDO9OPbHaMl34Ry6dPqUQ8D4bP7elJdvD-72H6szz9_-LR9e157ZeVcdz1obsByDVwjKm9aAUb2CgzafqNVp63dtb1q7K4zICXo3rTQgmh52VAn1elBdsrpekGa3RhofQoilv-csI22RnArC_ryH_QqLTmW41ZKtUrbDS-UOFA-J6KMvZtyGCF_dYK7NUt3yNKViNyapWvKzot75aUbcfdn43d4BZAHgMoo7jH_Zf1f1Z__xa40</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Theocharis, Stamatios</creator><creator>Giaginis, Constantinos</creator><creator>Alexandrou, Paraskevi</creator><creator>Rodriguez, Jose</creator><creator>Tasoulas, Jason</creator><creator>Danas, Eugene</creator><creator>Patsouris, Efstratios</creator><creator>Klijanienko, Jerzy</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients’ survival</title><author>Theocharis, Stamatios ; Giaginis, Constantinos ; Alexandrou, Paraskevi ; Rodriguez, Jose ; Tasoulas, Jason ; Danas, Eugene ; Patsouris, Efstratios ; Klijanienko, Jerzy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-bfa405a704a04ee3c591a52f3a5e7f643b477d9f387db5a22a4f59a9a190a043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Oral cancer</topic><topic>Original Article</topic><topic>Outcome Assessment (Health Care) - methods</topic><topic>Outcome Assessment (Health Care) - statistics & numerical data</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Receptor, Cannabinoid, CB1 - biosynthesis</topic><topic>Receptor, Cannabinoid, CB2 - biosynthesis</topic><topic>Sex Factors</topic><topic>Tongue Neoplasms - metabolism</topic><topic>Tongue Neoplasms - pathology</topic><topic>Tongue Neoplasms - surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Theocharis, Stamatios</creatorcontrib><creatorcontrib>Giaginis, Constantinos</creatorcontrib><creatorcontrib>Alexandrou, Paraskevi</creatorcontrib><creatorcontrib>Rodriguez, Jose</creatorcontrib><creatorcontrib>Tasoulas, Jason</creatorcontrib><creatorcontrib>Danas, Eugene</creatorcontrib><creatorcontrib>Patsouris, Efstratios</creatorcontrib><creatorcontrib>Klijanienko, Jerzy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Theocharis, Stamatios</au><au>Giaginis, Constantinos</au><au>Alexandrou, Paraskevi</au><au>Rodriguez, Jose</au><au>Tasoulas, Jason</au><au>Danas, Eugene</au><au>Patsouris, Efstratios</au><au>Klijanienko, Jerzy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients’ survival</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>37</volume><issue>3</issue><spage>3647</spage><epage>3656</epage><pages>3647-3656</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>Cannabinoid receptors (CB1R and CB2R) constitute essential members of the endocannabinoid system (ECS) which participates in many different functions indispensable to homeostatic regulation in several tissues, exerting also antitumorigenic effects. The present study aimed to assess the clinical significance of CB1R and CB2R protein expression in mobile tongue squamous cell carcinoma (SCC). CB1R and CB2R expression was assessed immunohistochemically on 28 mobile tongue SCC tissue samples and was analyzed in relation with clinicopathological characteristics and overall and disease-free patients’ survival. CB1R, CB2R, and concomitant CB1R/CB2R expression was significantly increased in older compared to younger mobile tongue SCC patients (
p
= 0.0243,
p
= 0.0079, and
p
= 0.0366, respectively). Enhanced CB2R and concomitant CB1R/CB2R expression was significantly more frequently observed in female compared to male mobile tongue SCC patients (
p
= 0.0025 and
p
= 0.0016, respectively). Elevated CB2R expression was significantly more frequently observed in mobile tongue SCC patients presenting well-defined tumor shape compared to those with diffuse (
p
= 0.0430). Mobile tongue SCC patients presenting enhanced CB1R, CB2R, or concomitant CB1R/CB2R expression showed significantly longer overall (log-rank test,
p
= 0.004,
p
= 0.011,
p
= 0.018, respectively) and disease-free (log-rank test,
p
= 0.003,
p
= 0.007,
p
= 0.027, respectively) survival times compared to those with low expression. In multivariate analysis, CB1R was identified as an independent prognostic factor for disease-free patients’ survival (Cox-regression analysis,
p
= 0.032). The present study provides evidence that CB1R and CB2R may play a role in the pathophysiological aspects of the mobile tongue SCC and even each molecule may constitute a potential target for the development of novel anti-cancer drugs for this type of malignancy.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>26459312</pmid><doi>10.1007/s13277-015-4182-8</doi><tpages>10</tpages></addata></record> |
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| ispartof | Tumor biology, 2016-03, Vol.37 (3), p.3647-3656 |
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| subjects | Adult Age Factors Aged Aged, 80 and over Biomarkers, Tumor - biosynthesis Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Female Humans Immunohistochemistry Kaplan-Meier Estimate Male Medical prognosis Middle Aged Multivariate Analysis Oral cancer Original Article Outcome Assessment (Health Care) - methods Outcome Assessment (Health Care) - statistics & numerical data Pathology Prognosis Proportional Hazards Models Receptor, Cannabinoid, CB1 - biosynthesis Receptor, Cannabinoid, CB2 - biosynthesis Sex Factors Tongue Neoplasms - metabolism Tongue Neoplasms - pathology Tongue Neoplasms - surgery Tumors |
| title | Evaluation of cannabinoid CB1 and CB2 receptors expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients’ survival |
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