Mechanism of metformin action in MCF-7 and MDA-MB-231 human breast cancer cells involves oxidative stress generation, DNA damage, and transforming growth factor β1 induction

The participation of oxidative stress in the mechanism of metformin action in breast cancer remains unclear. We investigated the effects of clinical (6 and 30 μM) and experimental concentrations of metformin (1000 and 5000 μM) in MCF-7 and in MDA-MB-231 cells, verifying cytotoxicity, oxidative stres...

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Veröffentlicht in:	Tumor biology 2016-04, Vol.37 (4), p.5337-5346
Hauptverfasser:	Marinello, Poliana Camila, da Silva, Thamara Nishida Xavier, Panis, Carolina, Neves, Amanda Fouto, Machado, Kaliana Larissa, Borges, Fernando Henrique, Guarnier, Flávia Alessandra, Bernardes, Sara Santos, de-Freitas-Junior, Júlio Cesar Madureira, Morgado-Díaz, José Andrés, Luiz, Rodrigo Cabral, Cecchini, Rubens, Cecchini, Alessandra Lourenço
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cancer Research Cell Proliferation - drug effects DNA Damage - drug effects Female Gene Expression Regulation, Neoplastic - drug effects Humans MCF-7 Cells Metformin - administration & dosage Original Article Oxidative Stress - drug effects Reactive Oxygen Species - metabolism Signal Transduction Transforming Growth Factor beta1 - biosynthesis Transforming Growth Factor beta1 - genetics Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics
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