Genetic variants in the ITGB6 gene is associated with the risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy

The αvβ6 integrin is a cell surface adhesion molecule that plays critical roles in the injury and inflammation processes. We hypothesized that polymorphisms in αvβ6 integrin genes (ITGAV and ITGB6) might be associated with the risk of radiation pneumonitis (RP) in lung cancer patients treated with t...

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Veröffentlicht in:	Tumor biology 2016-03, Vol.37 (3), p.3469-3477
Hauptverfasser:	Yi, Minxiao, Tang, Yang, Liu, Bo, Li, Qianxia, Zhou, Xiao, Yu, Shiying, Fu, Shengling, Cai, Yixin, Yuan, Xianglin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, Neoplasm - genetics Biomedical and Life Sciences Biomedicine Cancer Research Cell adhesion & migration Female Genes Genotype Humans Integrins - genetics Lung cancer Lung Neoplasms - radiotherapy Male Middle Aged Original Article Polymorphism Polymorphism, Single Nucleotide Radiation Pneumonitis - etiology Radiation Pneumonitis - genetics Radiation therapy Risk Thorax - radiation effects
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