Inhibition of Glut1 by WZB117 sensitizes radioresistant breast cancer cells to irradiation

Purpose Breast cancer is the most common type of cancer with high incidence in women. Currently, identifying new therapies that selectively inhibit tumor growth without damaging normal tissue are a major challenge of cancer research. One of the features of cancer cells is that they do not consume mo...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2016-05, Vol.77 (5), p.963-972
Hauptverfasser:	Zhao, Fei, Ming, Jia, Zhou, Yan, Fan, Linjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Cancer Research Cell Culture Techniques Cell Survival - drug effects Cell Survival - radiation effects Female Glucose - metabolism Glucose Transporter Type 1 - antagonists & inhibitors Glucose Transporter Type 1 - genetics Humans Hydroxybenzoates - pharmacology Immunohistochemistry MCF-7 Cells Medicine Medicine & Public Health Oncology Original Article Pharmacology/Toxicology Radiation Tolerance - drug effects Radiation-Sensitizing Agents - pharmacology Real-Time Polymerase Chain Reaction Transfection
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