Dendrimer-Templated Ultrasmall and Multifunctional Photothermal Agents for Efficient Tumor Ablation
Ultrasmall and multifunctional nanoparticles are highly desirable for photothermal cancer therapy, but the synthesis of these nanoparticles remains a huge challenge. Here, we used a dendrimer as a template to synthesize ultrasmall photothermal agents and further modified them with multifunctional gr...
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| Veröffentlicht in: | ACS nano 2016-04, Vol.10 (4), p.4863-4872 |
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| creator | Zhou, Zhengjie Wang, Yitong Yan, Yang Zhang, Qiang Cheng, Yiyun |
| description | Ultrasmall and multifunctional nanoparticles are highly desirable for photothermal cancer therapy, but the synthesis of these nanoparticles remains a huge challenge. Here, we used a dendrimer as a template to synthesize ultrasmall photothermal agents and further modified them with multifunctional groups. Dendrimer-encapsulated nanoparticles (DENPs) including copper sulfide, platinum, and palladium nanoparticles possessed a sub-5 nm size and exhibited an excellent photothermal effect. DENPs were further modified with TAT or RGD peptides to facilitate their cellular uptake and targeting delivery to tumors. They were also decorated with fluorescent probes for real-time imaging and tracking of the particles’ distribution. The in vivo study revealed RGD-modified DENPs efficiently reduced the tumor growth upon near-infrared irradiation. In all, our study provides a facile and flexible scaffold to prepare ultrasmall and multifunctional photothermal agents. |
| doi_str_mv | 10.1021/acsnano.6b02058 |
| format | Article |
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Here, we used a dendrimer as a template to synthesize ultrasmall photothermal agents and further modified them with multifunctional groups. Dendrimer-encapsulated nanoparticles (DENPs) including copper sulfide, platinum, and palladium nanoparticles possessed a sub-5 nm size and exhibited an excellent photothermal effect. DENPs were further modified with TAT or RGD peptides to facilitate their cellular uptake and targeting delivery to tumors. They were also decorated with fluorescent probes for real-time imaging and tracking of the particles’ distribution. The in vivo study revealed RGD-modified DENPs efficiently reduced the tumor growth upon near-infrared irradiation. 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In all, our study provides a facile and flexible scaffold to prepare ultrasmall and multifunctional photothermal agents.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Copper - chemistry</subject><subject>Dendrimers - chemistry</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Humans</subject><subject>Light</subject><subject>Male</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Oligopeptides - chemistry</subject><subject>Optical Imaging - methods</subject><subject>Palladium - chemistry</subject><subject>Particle Size</subject><subject>Peptide Fragments - chemistry</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Phototherapy - methods</subject><subject>Platinum - chemistry</subject><subject>Surface Properties</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EoqUws6GMSCjUjzhOx6qUh1QEQyuxWY4fNJUTF9sZ-PcYNXRjuvdI3znDB8A1gvcIYjQVMnSic_dlDTGk1QkYoxkpc1iVH6fHn6IRuAhhByFlFSvPwQgzSAtK6RjIB90p37Ta52vd7q2IWmUbG70IrbA2E53KXnsbG9N3MjauEzZ737ro4lb7RGTzT93FkBnns6UxjWxSzNZ9m_K8TnOpcgnOjLBBXw13AjaPy_XiOV-9Pb0s5qtcEEJizmossMbUFFQwbBSlRUrIUFlApcoZqxWmRFaE4qIoITIlgbOqxpogKDU1ZAJuD7t77756HSJvmyC1taLTrg8csapgBavwLKHTAyq9C8Frw_dJgvDfHEH-a5YPZvlgNjVuhvG-brU68n8qE3B3AFKT71zvk6rw79wPU6aFTA</recordid><startdate>20160426</startdate><enddate>20160426</enddate><creator>Zhou, Zhengjie</creator><creator>Wang, Yitong</creator><creator>Yan, Yang</creator><creator>Zhang, Qiang</creator><creator>Cheng, Yiyun</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160426</creationdate><title>Dendrimer-Templated Ultrasmall and Multifunctional Photothermal Agents for Efficient Tumor Ablation</title><author>Zhou, Zhengjie ; Wang, Yitong ; Yan, Yang ; Zhang, Qiang ; Cheng, Yiyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a333t-7b2a2e25f45a72fd554e251f5c40dd697bd253c835244601f63098b2e310ce5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Copper - chemistry</topic><topic>Dendrimers - chemistry</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Humans</topic><topic>Light</topic><topic>Male</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Oligopeptides - chemistry</topic><topic>Optical Imaging - methods</topic><topic>Palladium - chemistry</topic><topic>Particle Size</topic><topic>Peptide Fragments - chemistry</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Phototherapy - methods</topic><topic>Platinum - chemistry</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Zhengjie</creatorcontrib><creatorcontrib>Wang, Yitong</creatorcontrib><creatorcontrib>Yan, Yang</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Cheng, Yiyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Zhengjie</au><au>Wang, Yitong</au><au>Yan, Yang</au><au>Zhang, Qiang</au><au>Cheng, Yiyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendrimer-Templated Ultrasmall and Multifunctional Photothermal Agents for Efficient Tumor Ablation</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2016-04-26</date><risdate>2016</risdate><volume>10</volume><issue>4</issue><spage>4863</spage><epage>4872</epage><pages>4863-4872</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>Ultrasmall and multifunctional nanoparticles are highly desirable for photothermal cancer therapy, but the synthesis of these nanoparticles remains a huge challenge. 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| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use Cell Line, Tumor Cell Survival - drug effects Copper - chemistry Dendrimers - chemistry Fluorescent Dyes - chemistry Humans Light Male Metal Nanoparticles - chemistry Mice Mice, Inbred BALB C Oligopeptides - chemistry Optical Imaging - methods Palladium - chemistry Particle Size Peptide Fragments - chemistry Photosensitizing Agents - chemistry Photosensitizing Agents - therapeutic use Phototherapy - methods Platinum - chemistry Surface Properties |
| title | Dendrimer-Templated Ultrasmall and Multifunctional Photothermal Agents for Efficient Tumor Ablation |
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