Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers
Background The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. Methods The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correl...
Gespeichert in:
| Veröffentlicht in: | Head & neck 2016-04, Vol.38 (S1), p.E1788-E1793 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | E1793 |
|---|---|
| container_issue | S1 |
| container_start_page | E1788 |
| container_title | Head & neck |
| container_volume | 38 |
| creator | Lee, Doh Young Park, Min Woo Oh, Kyoung Ho Cho, Jae-Gu Kwon, Soon-Young Woo, Jeong-Soo Jung, Kwang Yoon Baek, Seung-Kuk |
| description | Background
The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer.
Methods
The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence‐free survival (RFS) according to histologic grade.
Results
Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low‐grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high‐grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low‐grade cancer (8.3%) and distant at high‐grade cancer (13.6%). The duration of RFS was significantly longer in low‐grade cancer than high‐grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively).
Conclusion
Consideration of different factors may be required for individual low‐grade and high‐grade parotid cancers when predicting the risk of recurrence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1788–E1793, 2016 |
| doi_str_mv | 10.1002/hed.24316 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1784744741</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1784744741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3636-c8b1665e74e479704feffe410f490c2bbf9c8b194912e63eba49e45d412d1d723</originalsourceid><addsrcrecordid>eNp1kMtKAzEUhoMo3he-gGSpi7G5NWmWUq9QKoiXhYuQyZzpRKeTmkypvr1T27oTDpzD4fu_xY_QCSUXlBDWq6C4YIJTuYX2KdEqI1yo7eUteMaJEnvoIKV3QgiXgu2iPSalHnCm99HbsPaNd2Fm2yrUYeIdLq1rQ0zYphScty0UeOHbCkdw8xihcYB9g-uwyLBtClz5SZVNoi0Az2wMrS-wsx0U0xHaKW2d4Hi9D9HzzfXT8C4bPdzeDy9HmeOSy8wNciplH5QAobQiooSyBEFJKTRxLM9LvUS00JSB5JBboUH0C0FZQQvF-CE6W3lnMXzOIbVm6pODurYNhHkyVA2EEt3QDj1foS6GlCKUZhb91MZvQ4lZdmm6Ls1vlx17utbO82n33ZCb8jqgtwIWvobv_03m7vpqo8xWCZ9a-PpL2PhhpOKqb17Ht-ZVjfpj-jg2L_wHJKGNPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1784744741</pqid></control><display><type>article</type><title>Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Lee, Doh Young ; Park, Min Woo ; Oh, Kyoung Ho ; Cho, Jae-Gu ; Kwon, Soon-Young ; Woo, Jeong-Soo ; Jung, Kwang Yoon ; Baek, Seung-Kuk</creator><creatorcontrib>Lee, Doh Young ; Park, Min Woo ; Oh, Kyoung Ho ; Cho, Jae-Gu ; Kwon, Soon-Young ; Woo, Jeong-Soo ; Jung, Kwang Yoon ; Baek, Seung-Kuk</creatorcontrib><description>Background
The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer.
Methods
The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence‐free survival (RFS) according to histologic grade.
Results
Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low‐grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high‐grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low‐grade cancer (8.3%) and distant at high‐grade cancer (13.6%). The duration of RFS was significantly longer in low‐grade cancer than high‐grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively).
Conclusion
Consideration of different factors may be required for individual low‐grade and high‐grade parotid cancers when predicting the risk of recurrence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1788–E1793, 2016</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.24316</identifier><identifier>PMID: 26698329</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Age Factors ; Aged ; Female ; grade ; Humans ; locoregional ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Grading ; Neoplasm Recurrence, Local - pathology ; parotid cancer ; Parotid Gland - pathology ; Parotid Neoplasms - pathology ; Prognosis ; recurrence ; Retrospective Studies ; Risk Factors ; survival</subject><ispartof>Head & neck, 2016-04, Vol.38 (S1), p.E1788-E1793</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3636-c8b1665e74e479704feffe410f490c2bbf9c8b194912e63eba49e45d412d1d723</citedby><cites>FETCH-LOGICAL-c3636-c8b1665e74e479704feffe410f490c2bbf9c8b194912e63eba49e45d412d1d723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.24316$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.24316$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26698329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Doh Young</creatorcontrib><creatorcontrib>Park, Min Woo</creatorcontrib><creatorcontrib>Oh, Kyoung Ho</creatorcontrib><creatorcontrib>Cho, Jae-Gu</creatorcontrib><creatorcontrib>Kwon, Soon-Young</creatorcontrib><creatorcontrib>Woo, Jeong-Soo</creatorcontrib><creatorcontrib>Jung, Kwang Yoon</creatorcontrib><creatorcontrib>Baek, Seung-Kuk</creatorcontrib><title>Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer.
Methods
The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence‐free survival (RFS) according to histologic grade.
Results
Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low‐grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high‐grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low‐grade cancer (8.3%) and distant at high‐grade cancer (13.6%). The duration of RFS was significantly longer in low‐grade cancer than high‐grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively).
Conclusion
Consideration of different factors may be required for individual low‐grade and high‐grade parotid cancers when predicting the risk of recurrence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1788–E1793, 2016</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Female</subject><subject>grade</subject><subject>Humans</subject><subject>locoregional</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>parotid cancer</subject><subject>Parotid Gland - pathology</subject><subject>Parotid Neoplasms - pathology</subject><subject>Prognosis</subject><subject>recurrence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>survival</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMo3he-gGSpi7G5NWmWUq9QKoiXhYuQyZzpRKeTmkypvr1T27oTDpzD4fu_xY_QCSUXlBDWq6C4YIJTuYX2KdEqI1yo7eUteMaJEnvoIKV3QgiXgu2iPSalHnCm99HbsPaNd2Fm2yrUYeIdLq1rQ0zYphScty0UeOHbCkdw8xihcYB9g-uwyLBtClz5SZVNoi0Az2wMrS-wsx0U0xHaKW2d4Hi9D9HzzfXT8C4bPdzeDy9HmeOSy8wNciplH5QAobQiooSyBEFJKTRxLM9LvUS00JSB5JBboUH0C0FZQQvF-CE6W3lnMXzOIbVm6pODurYNhHkyVA2EEt3QDj1foS6GlCKUZhb91MZvQ4lZdmm6Ls1vlx17utbO82n33ZCb8jqgtwIWvobv_03m7vpqo8xWCZ9a-PpL2PhhpOKqb17Ht-ZVjfpj-jg2L_wHJKGNPw</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Lee, Doh Young</creator><creator>Park, Min Woo</creator><creator>Oh, Kyoung Ho</creator><creator>Cho, Jae-Gu</creator><creator>Kwon, Soon-Young</creator><creator>Woo, Jeong-Soo</creator><creator>Jung, Kwang Yoon</creator><creator>Baek, Seung-Kuk</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201604</creationdate><title>Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers</title><author>Lee, Doh Young ; Park, Min Woo ; Oh, Kyoung Ho ; Cho, Jae-Gu ; Kwon, Soon-Young ; Woo, Jeong-Soo ; Jung, Kwang Yoon ; Baek, Seung-Kuk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3636-c8b1665e74e479704feffe410f490c2bbf9c8b194912e63eba49e45d412d1d723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Female</topic><topic>grade</topic><topic>Humans</topic><topic>locoregional</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>parotid cancer</topic><topic>Parotid Gland - pathology</topic><topic>Parotid Neoplasms - pathology</topic><topic>Prognosis</topic><topic>recurrence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Doh Young</creatorcontrib><creatorcontrib>Park, Min Woo</creatorcontrib><creatorcontrib>Oh, Kyoung Ho</creatorcontrib><creatorcontrib>Cho, Jae-Gu</creatorcontrib><creatorcontrib>Kwon, Soon-Young</creatorcontrib><creatorcontrib>Woo, Jeong-Soo</creatorcontrib><creatorcontrib>Jung, Kwang Yoon</creatorcontrib><creatorcontrib>Baek, Seung-Kuk</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Doh Young</au><au>Park, Min Woo</au><au>Oh, Kyoung Ho</au><au>Cho, Jae-Gu</au><au>Kwon, Soon-Young</au><au>Woo, Jeong-Soo</au><au>Jung, Kwang Yoon</au><au>Baek, Seung-Kuk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2016-04</date><risdate>2016</risdate><volume>38</volume><issue>S1</issue><spage>E1788</spage><epage>E1793</epage><pages>E1788-E1793</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer.
Methods
The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence‐free survival (RFS) according to histologic grade.
Results
Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low‐grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high‐grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low‐grade cancer (8.3%) and distant at high‐grade cancer (13.6%). The duration of RFS was significantly longer in low‐grade cancer than high‐grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively).
Conclusion
Consideration of different factors may be required for individual low‐grade and high‐grade parotid cancers when predicting the risk of recurrence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1788–E1793, 2016</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26698329</pmid><doi>10.1002/hed.24316</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 2016-04, Vol.38 (S1), p.E1788-E1793 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1784744741 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Age Factors Aged Female grade Humans locoregional Male Middle Aged Multivariate Analysis Neoplasm Grading Neoplasm Recurrence, Local - pathology parotid cancer Parotid Gland - pathology Parotid Neoplasms - pathology Prognosis recurrence Retrospective Studies Risk Factors survival |
| title | Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T00%3A06%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinicopathologic%20factors%20associated%20with%20recurrence%20in%20low-%20and%20high-grade%20parotid%20cancers&rft.jtitle=Head%20&%20neck&rft.au=Lee,%20Doh%20Young&rft.date=2016-04&rft.volume=38&rft.issue=S1&rft.spage=E1788&rft.epage=E1793&rft.pages=E1788-E1793&rft.issn=1043-3074&rft.eissn=1097-0347&rft_id=info:doi/10.1002/hed.24316&rft_dat=%3Cproquest_cross%3E1784744741%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1784744741&rft_id=info:pmid/26698329&rfr_iscdi=true |