Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity

It has been shown that intratumor administration of an adenovirus vector expressing IL-12 produces a potent T cell-mediated response that leads to significant tumor regression in a murine breast cancer model. IP-10 and MIG are CXC chemokines that recruit mononuclear cells in vivo. In addition to the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gene therapy 2001-02, Vol.8 (4), p.282-290
Hauptverfasser:	PALMER, K, HITT, M, EMTAGE, P. C. R, GYORFFY, S, GAULDIE, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenoviridae - genetics Adenovirus Adenoviruses Angiogenesis Animal models Animals Antitumor activity Biological and medical sciences Biotechnology Blotting, Northern Breast cancer CD3 Complex - analysis CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Chemokines, CXC - genetics Collagen CXC chemokines Cytotoxicity Tests, Immunologic Drug Combinations Endothelium, Vascular - pathology Expression vectors Female Fibroblast Growth Factor 2 - pharmacology Fibrosarcoma Fundamental and applied biological sciences. Psychology Gene therapy Gene transfer Genetic Therapy - methods Genetic Vectors - administration & dosage Health. Pharmaceutical industry Immunity Industrial applications and implications. Economical aspects Injections, Intralesional Interferon-gamma - analysis Interleukin 12 Interleukin-12 - genetics Interleukin-4 - analysis IP-10 protein Laminin Leukocytes (mononuclear) Lymphocytes T Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - therapy Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Nude Neovascularization, Pathologic Proteoglycans T-Lymphocytes - immunology Tumors Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!