Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma

The oral squamous cell carcinoma (OSCC) is one of the most common malignant epithelial neoplasms and considered to be caused by the genetic damage. In addition, smoking habit and excessive alcohol consumption have been estimated to be the main risk factors. Although the association between OSCC and...

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Veröffentlicht in:	Tumor biology 2016-02, Vol.37 (2), p.1845-1851
Hauptverfasser:	Sun, Wei, Lv, Wenhua, Lv, Hongchao, Zhang, Ruijie, Jiang, Yongshuai
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Drinking - adverse effects Analysis Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - genetics Case-Control Studies Genetic Predisposition to Disease - genetics Genetics Genome-Wide Association Study - methods Haplotypes - genetics Humans Intracellular Signaling Peptides and Proteins - genetics Membrane Glycoproteins - genetics Mouth Neoplasms - etiology Mouth Neoplasms - genetics Oral cancer Original Article Polymorphism, Single Nucleotide - genetics Protein-Serine-Threonine Kinases - genetics Risk Risk Factors Serpin E2 - genetics Serpins - genetics Smoking - adverse effects Smoking - genetics
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