Differential immunohistochemical expression profiles of perlecan-binding growth factors in epithelial dysplasia, carcinoma in situ, and squamous cell carcinoma of the oral mucosa

The intercellular deposit of perlecan, a basement-membrane type heparan sulfate proteoglycan, is considered to function as a growth factor reservoir and is enhanced in oral epithelial dysplasia and carcinoma in situ (CIS). However, it remains unknown which types of growth factors function in these p...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2016-05, Vol.212 (5), p.426-436
Hauptverfasser:	Hasegawa, Mayumi, Cheng, Jun, Maruyama, Satoshi, Yamazaki, Manabu, Abé, Tatsuya, Babkair, Hamzah, Saito, Chikara, Saku, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma in situ Carcinoma in Situ - metabolism Carcinoma in Situ - pathology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell proliferating zone Cell Proliferation - physiology Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial dysplasia Epithelium - metabolism Epithelium - pathology Fibroblast Growth Factor 7 - metabolism Hedgehog Proteins - metabolism Heparan Sulfate Proteoglycans - metabolism Humans Hyperplasia - metabolism Hyperplasia - pathology Mouth Mucosa - metabolism Mouth Mucosa - pathology Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Oral squamous cell carcinoma Perlecan Perlecan-binding growth factors Precancerous Conditions - metabolism Precancerous Conditions - pathology Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism
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