Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y sub(12) receptor-mediated inhibition of voltage-gated Ca super(2+) channels

Although feedback inhibition of noradrenaline release by coreleased nucleotides is a well known phenomenon, it remained unclear which P2 receptor subtypes and associated signalling cascades may be involved. In the rat pheochromocytoma cell line PC12, 2-methylthio-ADP reduced noradrenaline release tr...

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Veröffentlicht in:The European journal of neuroscience 2004-12, Vol.20 (11), p.2917-2928
Hauptverfasser: Lechner, Stefan G, Dorostkar, Mario M, Mayer, Martina, Edelbauer, Hannah, Pankevych, Halyna, Boehm, Stefan
Format: Artikel
Sprache:eng
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