Effects of HIV drug combinations on endothelin-1 and vascular cell proliferation

Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature involving endothelial and vascular smooth muscle cell (VSMC) proliferation, vasoconstriction, right ventricular hypertrophy, and eventually, right heart failure and death. PAH occurs 1000-fold more frequently...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cardiovascular toxicology 2004, Vol.4 (2), p.117-132
Hauptverfasser:	Hebert, Valeria Y, Crenshaw, Brian L, Romanoff, Rachelle L, Ekshyyan, Viktoriya P, Dugas, Tammy R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiretroviral Therapy, Highly Active Cell Proliferation - drug effects Cell Respiration - drug effects Cells, Cultured Coculture Techniques Dose-Response Relationship, Drug Drug Interactions Drug therapy Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelin A Receptor Antagonists Endothelin-1 - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female HIV HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - toxicity Human immunodeficiency virus Humans Indinavir - administration & dosage Indinavir - toxicity Male Mitochondria - drug effects Mitochondria - metabolism Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Rats Rats, Sprague-Dawley Umbilical Veins - cytology Zidovudine - administration & dosage Zidovudine - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!