Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

Bcl10, a CARD-containing protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas, has been shown to induce apoptosis and activate NF- κ B in vitro. We show that one-third of bcl10 −/− embryos developed exencephaly, leading to embryonic lethality. Surprisingly, bcl10 −/− cells retai...

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Veröffentlicht in:	Cell 2001-01, Vol.104 (1), p.33-42
Hauptverfasser:	Ruland, Jürgen, Duncan, Gordon S, Elia, Andrew, del Barco Barrantes, Ivan, Nguyen, Linh, Plyte, Sue, Millar, Douglas G, Bouchard, Denis, Wakeham, Andrew, Ohashi, Pamela S, Mak, Tak W
Format:	Artikel
Sprache:	eng
Schlagworte:	Bcl-10 protein Bcl10 protein NF-B protein
Online-Zugang:	Volltext
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