Prion Protein: Evolution Caught en Route

The prion protein displays a unique structural ambiguity in that it can adopt multiple stable conformations under physiological conditions. In our view, this puzzling feature resulted from a sudden environmental change in evolution when the prion, previously an integral membrane protein, got expelle...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-04, Vol.98 (8), p.4431-4436
Hauptverfasser:	Tompa, P., Tusnády, G. E., Cserző, M., Simon, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Evolution Evolution, Molecular Genetic mutation Globulins Membrane proteins Prion diseases Prions Prions - chemistry Prions - genetics Protein Conformation Proteins Spongiform encephalopathies Topology Transmembrane proteins
Online-Zugang:	Volltext
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