Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans

Two new 13-membered macrolides (1, 7), along with known 13-membered macrolides PF1163A, B, D, H, and F (2–6), were isolated from a strain of a marine-derived fungus, Penicillium meleagrinum var. viridiflavum. The structures of 1 and 7 were elucidated from spectroscopic data (NMR, MS, IR). Compounds...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2016-04, Vol.79 (4), p.1208-1212
Hauptverfasser:	Okabe, Miki, Sugita, Takashi, Kinoshita, Kaoru, Koyama, Kiyotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Azoles - pharmacology Candida albicans - drug effects Drug Synergism Fluconazole - pharmacology Macrolides - chemistry Macrolides - isolation & purification Macrolides - pharmacology Marine Biology Molecular Structure Penicillium - chemistry
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