The pathobiology of pig-to-primate xenotransplantation: a historical review

The immunologic barriers to successful xenotransplantation are related to the presence of natural anti‐pig antibodies in humans and non‐human primates that bind to antigens expressed on the transplanted pig organ (the most important of which is galactose‐α1,3‐galactose [Gal]), and activate the compl...

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Veröffentlicht in:	Xenotransplantation (Københaven) 2016-03, Vol.23 (2), p.83-105
Hauptverfasser:	Cooper, David K.C., Ezzelarab, Mohamed B., Hara, Hidetaka, Iwase, Hayato, Lee, Whayoung, Wijkstrom, Martin, Bottino, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified - immunology Graft Rejection - immunology Graft Rejection - pathology Graft Survival - immunology Humans islets Non-human primate organs Pathobiology Pig Primates Sus scrofa - immunology Transplantation, Heterologous - methods Xenotransplantation
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