T-helper type 2 cell-specific expression of the ST2 gene is regulated by transcription factor GATA-3

ST2 is a member of the interleukin-1 receptor family and is expressed in type-2 T helper (Th2) cells. Here, we have studied the molecular mechanism responsible for the transcriptional regulation of the ST2 gene in Th2 cells using a mouse thymoma cell line, EL-4. The ST2 gene has distal and proximal...

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Veröffentlicht in:	Biochimica et biophysica acta 2005-04, Vol.1728 (1), p.53-64
Hauptverfasser:	Hayakawa, Morisada, Yanagisawa, Ken, Aoki, Shinsuke, Hayakawa, Hiroko, Takezako, Naoki, Tominaga, Shin-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Blotting, Western Bucladesine - pharmacology Cell Line DNA Primers DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Electrophoretic Mobility Shift Assay GATA-3 GATA3 Transcription Factor Gene Components Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Interleukin-1 receptor family Interleukin-1 Receptor-Like 1 Protein Luciferases Membrane Proteins - genetics Membrane Proteins - metabolism Mice Molecular Sequence Data Plasmids - genetics Receptors, Interleukin Reverse Transcriptase Polymerase Chain Reaction ST2 T-Lymphocytes, Helper-Inducer - metabolism Tetradecanoylphorbol Acetate - pharmacology Trans-Activators - genetics Trans-Activators - metabolism Transfection Type-2 T helper cell
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