Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity

Polychlorinated biphenyls (PCBs) are ubiquitous environmental persistent contaminants giving rise to potential health hazard. Some PCBs exert dioxin-like activities mediated through the aryl hydrocarbon receptor. Although reports on interaction with other nuclear receptors are sparce, some congeners...

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Veröffentlicht in:	Toxicology (Amsterdam) 2001-02, Vol.158 (3), p.141-153
Hauptverfasser:	Bonefeld-Jørgensen, Eva Cecilie, Andersen, Helle Raun, Rasmussen, Thomas Høj, Vinggaard, Anne Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	AAh receptors AH-receptor Androgen receptor Androgen Receptor Antagonists androgen receptors Animals Biological and medical sciences Breast cancer cells Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Division - drug effects Chemical and industrial products toxicology. Toxic occupational diseases CHO Cells Cricetinae Cricetulus Environmental Pollutants - pharmacokinetics Environmental Pollutants - toxicity Estradiol - pharmacology Estrogen receptor estrogen receptors Gene Expression Regulation, Neoplastic Genes, Reporter - drug effects Humans Luciferases - analysis Medical sciences PCB Polychlorinated Biphenyls - pharmacokinetics Polychlorinated Biphenyls - toxicity Receptors, Androgen - genetics Receptors, Androgen - physiology Receptors, Estrogen - genetics Receptors, Estrogen - physiology TCDD Toxicology Transcriptional Activation Transfection Tumor Cells, Cultured Various organic compounds
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