Glucocorticoid Receptor Ligand Binding Domain Is Sufficient for the Modulation of Glucocorticoid Induction Properties by Homologous Receptors, Coactivator Transcription Intermediary Factor 2, and Ubc9

Several factors modulate the position of the dose-response curve of steroid receptor-agonist complexes and the partial agonist activity of antagonist complexes, thereby causing differential gene activation by circulating hormones and unequal gene repression during endocrine therapies with antisteroi...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2005-02, Vol.19 (2), p.290-311
Hauptverfasser:	Cho, Sehyung, Kagan, Benjamin L, Blackford, John A, Szapary, Daniele, Simons, S. Stoney
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Line Cell-Free System COS Cells Dexamethasone - pharmacology Dimerization DNA - metabolism Dose-Response Relationship, Drug Gene Expression Regulation Genes, Dominant Glucocorticoids - metabolism Glutathione - chemistry Glutathione Transferase - metabolism Kinetics Ligands Mutagenesis, Site-Directed Mutation Nuclear Receptor Coactivator 2 Plasmids - metabolism Protein Binding Protein Biosynthesis Protein Structure, Tertiary Rats Receptors, Glucocorticoid - chemistry Receptors, Glucocorticoid - metabolism Sepharose - chemistry Steroids - chemistry Steroids - metabolism Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection Ubiquitin-Conjugating Enzymes - metabolism
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