Therapeutic effect of adenoviral-mediated hepatocyte growth factor gene administration on TNBS-induced colitis in mice

Inflammatory bowel disease is incurable and relapsing disease. In order to clarify the effect of HGF gene therapy for inflammatory bowel disease, the adenoviral-mediated HGF gene was intrarectally administered into TNBS-colitis-induced Balb/c mice. Adenoviral-mediated gene delivery targetted its exp...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-04, Vol.329 (4), p.1217-1224
Hauptverfasser:	Mukoyama, Tomoyuki, Kanbe, Takamasa, Murai, Rie, Murawaki, Yoshiyuki, Shimomura, Takashi, Hashiguchi, Ko-ichi, Saeki, Toshiya, Ichiba, Miho, Yoshida, Yoko, Tanabe, Naotada, Kurimasa, Akihiro, Harada, Ken-ichi, Yashima, Kazuo, Hisatome, Ichiro, Ito, Hisao, Murawaki, Yoshikazu, Shiota, Goshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Administration, Rectal Animals Apoptosis Body Weight - genetics Cell Proliferation Colitis - chemically induced Colitis - genetics Colitis - pathology Colitis - therapy Female Gene Expression Gene therapy Genetic Therapy Hepatocyte growth factor Hepatocyte Growth Factor - administration & dosage Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Mice Mice, Inbred BALB C TNBS-colitis Trinitrobenzenesulfonic Acid - administration & dosage Trinitrobenzenesulfonic Acid - pharmacology
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