Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage

Telomere shortening limits the regenerative capacity of cells during aging and chronic disease but at the same time inhibits tumor progression, and it has yet to be determined which of these mechanisms is dominantly affecting organismal survival. Here we show that telomere shortening in telomerase k...

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Veröffentlicht in:	Oncogene 2005-02, Vol.24 (9), p.1501-1509
Hauptverfasser:	Wiemann, Stefanie U, Satyanarayana, Ande, Buer, Jan, Kamino, Kenji, Manns, Michael P, Rudolph, Karl Lenhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Aging Animals Apoptosis beta Catenin Biological and medical sciences Cancer Carbon Tetrachloride Poisoning Cell Biology Cell cycle Cell Division Cell Nucleus - pathology Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chronic illnesses Cytoskeletal Proteins - analysis DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Gene expression Gene transfer Hepatocytes Homeostasis Human Genetics Hypotheses Internal Medicine Liver Liver - pathology Liver Neoplasms - pathology Liver Neoplasms - prevention & control Medicine Medicine & Public Health Mice Mice, Knockout Mice, Transgenic Molecular and cellular biology Oncology original-paper Senescence Telomerase Telomerase - deficiency Telomerase - genetics Telomerase - metabolism Telomeres Trans-Activators - analysis Tumor suppression Tumors
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