Molecular cloning and chromosomal localization of human salt-tolerant protein
We have isolated a novel human cDNA coding for human salt-tolerant protein (HSTP), that is a homologue of the rat salt-tolerant protein (STP) and may contribute to salt-induced hypertension by modulating renal cation transport. The nucleotide sequence (1988bp) of the HSTP cDNA contains an open readi...
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| Veröffentlicht in: | Genetica 2000-01, Vol.108 (3), p.259-262 |
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| container_title | Genetica |
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| creator | Tsuji, E Tsuji, Y |
| description | We have isolated a novel human cDNA coding for human salt-tolerant protein (HSTP), that is a homologue of the rat salt-tolerant protein (STP) and may contribute to salt-induced hypertension by modulating renal cation transport. The nucleotide sequence (1988bp) of the HSTP cDNA contains an open reading frame encoding a polypeptide comprising 545 amino acids, two residues fewer than the rat STP cDNA. The predicted amino acid sequence exhibits 92% identity to that of the rat protein. HSTP contains predicted coiled-coil domains and Src Homology 3 domain, and shows a high degree of identity to CIP4 (Cdc42 target protein) and human Trip 10 (thyroid-hormone receptor interacting protein). We have mapped the HSTP gene to human chromosome 19 by fluorescence in situ hybridization. |
| doi_str_mv | 10.1023/A:1004132919896 |
| format | Article |
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The nucleotide sequence (1988bp) of the HSTP cDNA contains an open reading frame encoding a polypeptide comprising 545 amino acids, two residues fewer than the rat STP cDNA. The predicted amino acid sequence exhibits 92% identity to that of the rat protein. HSTP contains predicted coiled-coil domains and Src Homology 3 domain, and shows a high degree of identity to CIP4 (Cdc42 target protein) and human Trip 10 (thyroid-hormone receptor interacting protein). We have mapped the HSTP gene to human chromosome 19 by fluorescence in situ hybridization.</description><identifier>ISSN: 0016-6707</identifier><identifier>EISSN: 1573-6857</identifier><identifier>DOI: 10.1023/A:1004132919896</identifier><identifier>PMID: 11294612</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Amino Acid Sequence ; Amino acids ; Animals ; Carrier Proteins - chemistry ; Carrier Proteins - genetics ; Carrier Proteins - physiology ; Cdc42 target protein ; chromosome 19 ; Chromosome Mapping ; Chromosomes, Human, Pair 19 - genetics ; CIP4 protein ; Cloning ; Cloning, Molecular ; DNA, Complementary - genetics ; DNA, Complementary - isolation & purification ; Humans ; Hypertension ; Hypertension - etiology ; In Situ Hybridization, Fluorescence ; Microtubule-Associated Proteins ; Minor Histocompatibility Antigens ; Molecular Sequence Data ; Proteins ; Rats ; salt-tolerant protein ; Salts ; Sequence Homology, Amino Acid ; Sodium Chloride, Dietary - adverse effects ; Thyroid ; thyroid-hormone receptor interacting protein ; Trip 10 protein</subject><ispartof>Genetica, 2000-01, Vol.108 (3), p.259-262</ispartof><rights>Kluwer Academic Publishers 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-a8560e688d2de9137f97ec97bdbc1fd73b33997a867c30fd7a3671478030111c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11294612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuji, E</creatorcontrib><creatorcontrib>Tsuji, Y</creatorcontrib><title>Molecular cloning and chromosomal localization of human salt-tolerant protein</title><title>Genetica</title><addtitle>Genetica</addtitle><description>We have isolated a novel human cDNA coding for human salt-tolerant protein (HSTP), that is a homologue of the rat salt-tolerant protein (STP) and may contribute to salt-induced hypertension by modulating renal cation transport. The nucleotide sequence (1988bp) of the HSTP cDNA contains an open reading frame encoding a polypeptide comprising 545 amino acids, two residues fewer than the rat STP cDNA. The predicted amino acid sequence exhibits 92% identity to that of the rat protein. HSTP contains predicted coiled-coil domains and Src Homology 3 domain, and shows a high degree of identity to CIP4 (Cdc42 target protein) and human Trip 10 (thyroid-hormone receptor interacting protein). We have mapped the HSTP gene to human chromosome 19 by fluorescence in situ hybridization.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Carrier Proteins - chemistry</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - physiology</subject><subject>Cdc42 target protein</subject><subject>chromosome 19</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 19 - genetics</subject><subject>CIP4 protein</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>DNA, Complementary - genetics</subject><subject>DNA, Complementary - isolation & purification</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - etiology</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Microtubule-Associated Proteins</subject><subject>Minor Histocompatibility Antigens</subject><subject>Molecular Sequence Data</subject><subject>Proteins</subject><subject>Rats</subject><subject>salt-tolerant protein</subject><subject>Salts</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sodium Chloride, Dietary - adverse effects</subject><subject>Thyroid</subject><subject>thyroid-hormone receptor interacting protein</subject><subject>Trip 10 protein</subject><issn>0016-6707</issn><issn>1573-6857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkD1PwzAQhi0EoqUwsyGLgS3gy6U-m62q-JJascAcOY5LUzl2iZMBfj2RKAvTK52ee-70MnYJ4hZEjneLexCiAMw1aKXlEZvCnDCTak7HbCoEyEySoAk7S2knhNAk9SmbAOS6kJBP2XodvbODNx23PoYmfHATam63XWxjiq3x3EdrfPNt-iYGHjd8O7Qm8GR8n_XjcmdCz_dd7F0TztnJxvjkLg45Y--PD2_L52z1-vSyXKwyiwB9ZtRcCieVqvPaaUDaaHJWU1VXFjY1YYWoNRklyaIYBwYlQUFKoAAAizN28-sd734OLvVl2yTrvDfBxSGVQAqRRvOMXf8Dd3HowvhbSbJQusgljtDVARqq1tXlvmta032Vfy3hD55SaMQ</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Tsuji, E</creator><creator>Tsuji, Y</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope></search><sort><creationdate>20000101</creationdate><title>Molecular cloning and chromosomal localization of human salt-tolerant protein</title><author>Tsuji, E ; Tsuji, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-a8560e688d2de9137f97ec97bdbc1fd73b33997a867c30fd7a3671478030111c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Carrier Proteins - 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The nucleotide sequence (1988bp) of the HSTP cDNA contains an open reading frame encoding a polypeptide comprising 545 amino acids, two residues fewer than the rat STP cDNA. The predicted amino acid sequence exhibits 92% identity to that of the rat protein. HSTP contains predicted coiled-coil domains and Src Homology 3 domain, and shows a high degree of identity to CIP4 (Cdc42 target protein) and human Trip 10 (thyroid-hormone receptor interacting protein). We have mapped the HSTP gene to human chromosome 19 by fluorescence in situ hybridization.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>11294612</pmid><doi>10.1023/A:1004132919896</doi><tpages>4</tpages></addata></record> |
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| subjects | Amino Acid Sequence Amino acids Animals Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - physiology Cdc42 target protein chromosome 19 Chromosome Mapping Chromosomes, Human, Pair 19 - genetics CIP4 protein Cloning Cloning, Molecular DNA, Complementary - genetics DNA, Complementary - isolation & purification Humans Hypertension Hypertension - etiology In Situ Hybridization, Fluorescence Microtubule-Associated Proteins Minor Histocompatibility Antigens Molecular Sequence Data Proteins Rats salt-tolerant protein Salts Sequence Homology, Amino Acid Sodium Chloride, Dietary - adverse effects Thyroid thyroid-hormone receptor interacting protein Trip 10 protein |
| title | Molecular cloning and chromosomal localization of human salt-tolerant protein |
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