Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels

Sildenafil (Viagra) is a selective inhibitor of phosphodiesterase type 5 (PDE5), which degrades cyclic guanosine monophosphate to the linear nucleotide. Sildenafil is acutely used in erectile dysfunction and chronically in pulmonary hypertension. Evidence in the last decade shows that sildenafil may...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurochemistry 2016-01, Vol.136 (2), p.403-415
Hauptverfasser:	Gómez‐Vallejo, Vanessa, Ugarte, Ana, García‐Barroso, Carolina, Cuadrado‐Tejedor, Mar, Szczupak, Boguslaw, Dopeso‐Reyes, Iria G., Lanciego, José L., García‐Osta, Ana, Llop, Jordi, Oyarzabal, Julen, Franco, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Animals biodistribution Body fluids Brain - diagnostic imaging Brain - drug effects cerebrospinal fluid (CSF) cGMP Chromatography, Liquid Cyclic GMP - blood Cyclic GMP - cerebrospinal fluid Kidney - diagnostic imaging Kidney - drug effects Kinetics Liver - drug effects Liver - metabolism Macaca fascicularis Male neurodegeneration Neurological disorders nootropic Pharmacology Phosphodiesterase 5 Inhibitors - pharmacokinetics Positron emission tomography Rats Rats, Sprague-Dawley Sildenafil Citrate - pharmacokinetics Tandem Mass Spectrometry Testis - drug effects Testis - metabolism Time Factors Tissue Distribution - drug effects Tomography Tomography Scanners, X-Ray Computed
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!