Prevention of gentamicin ototoxicity with N-acetylcysteine and vitamin A
To investigate the use of systemic N-acetylcysteine and vitamin A in the prevention of gentamicin ototoxicity in rats. Forty-two Wistar rats were divided into four groups according to treatment: intratympanic saline, intratympanic gentamicin, intraperitoneal vitamin A after intratympanic gentamicin,...
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| Veröffentlicht in: | Journal of laryngology and otology 2016-05, Vol.130 (5), p.440-446 |
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| creator | Aladag, I Guven, M Songu, M |
| description | To investigate the use of systemic N-acetylcysteine and vitamin A in the prevention of gentamicin ototoxicity in rats.
Forty-two Wistar rats were divided into four groups according to treatment: intratympanic saline, intratympanic gentamicin, intraperitoneal vitamin A after intratympanic gentamicin, and intraperitoneal N-acetylcysteine after intratympanic gentamicin. Signal-to-noise ratio and distortion product otoacoustic emissions were evaluated in all groups.
N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 2, 3, 4 and 6 kHz, as determined by the distortion product otoacoustic emission measurements. According to the signal-to-noise measurements, N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 3, 6 and 8 kHz.
Gentamicin-induced hearing loss in rats may be prevented by the concomitant use of vitamin A and N-acetylcysteine. Specifically, N-acetylcysteine appeared to have a more protective effect than vitamin A for a greater range of noise frequencies. |
| doi_str_mv | 10.1017/S0022215116000992 |
| format | Article |
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Forty-two Wistar rats were divided into four groups according to treatment: intratympanic saline, intratympanic gentamicin, intraperitoneal vitamin A after intratympanic gentamicin, and intraperitoneal N-acetylcysteine after intratympanic gentamicin. Signal-to-noise ratio and distortion product otoacoustic emissions were evaluated in all groups.
N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 2, 3, 4 and 6 kHz, as determined by the distortion product otoacoustic emission measurements. According to the signal-to-noise measurements, N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 3, 6 and 8 kHz.
Gentamicin-induced hearing loss in rats may be prevented by the concomitant use of vitamin A and N-acetylcysteine. Specifically, N-acetylcysteine appeared to have a more protective effect than vitamin A for a greater range of noise frequencies.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S0022215116000992</identifier><identifier>PMID: 27095551</identifier><identifier>CODEN: JLOTAX</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acetylcysteine - pharmacology ; Acoustics ; Animals ; Anti-Bacterial Agents - toxicity ; Antibiotics ; Apoptosis ; Eardrum ; Ears & hearing ; Free Radical Scavengers - pharmacology ; Gentamicins - toxicity ; Hearing - drug effects ; Hearing loss ; Hearing Loss - chemically induced ; Hearing Loss - prevention & control ; Hearing protection ; Lipid peroxidation ; Main Articles ; Male ; Normal distribution ; Otoacoustic Emissions, Spontaneous - drug effects ; Rats ; Rats, Wistar ; Signal-To-Noise Ratio ; Vitamin A ; Vitamin A - pharmacology ; Vitamins - pharmacology</subject><ispartof>Journal of laryngology and otology, 2016-05, Vol.130 (5), p.440-446</ispartof><rights>Copyright © JLO (1984) Limited 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-7cd5b57d46c20349bb359d6ebcd6c5a623d0a7493a9a341e1a9948ddae8af64e3</citedby><cites>FETCH-LOGICAL-c421t-7cd5b57d46c20349bb359d6ebcd6c5a623d0a7493a9a341e1a9948ddae8af64e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022215116000992/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,782,786,27933,27934,55637</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27095551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aladag, I</creatorcontrib><creatorcontrib>Guven, M</creatorcontrib><creatorcontrib>Songu, M</creatorcontrib><title>Prevention of gentamicin ototoxicity with N-acetylcysteine and vitamin A</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>To investigate the use of systemic N-acetylcysteine and vitamin A in the prevention of gentamicin ototoxicity in rats.
Forty-two Wistar rats were divided into four groups according to treatment: intratympanic saline, intratympanic gentamicin, intraperitoneal vitamin A after intratympanic gentamicin, and intraperitoneal N-acetylcysteine after intratympanic gentamicin. Signal-to-noise ratio and distortion product otoacoustic emissions were evaluated in all groups.
N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 2, 3, 4 and 6 kHz, as determined by the distortion product otoacoustic emission measurements. According to the signal-to-noise measurements, N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 3, 6 and 8 kHz.
Gentamicin-induced hearing loss in rats may be prevented by the concomitant use of vitamin A and N-acetylcysteine. Specifically, N-acetylcysteine appeared to have a more protective effect than vitamin A for a greater range of noise frequencies.</description><subject>Acetylcysteine - pharmacology</subject><subject>Acoustics</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - toxicity</subject><subject>Antibiotics</subject><subject>Apoptosis</subject><subject>Eardrum</subject><subject>Ears & hearing</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Gentamicins - toxicity</subject><subject>Hearing - drug effects</subject><subject>Hearing loss</subject><subject>Hearing Loss - chemically induced</subject><subject>Hearing Loss - prevention & control</subject><subject>Hearing protection</subject><subject>Lipid peroxidation</subject><subject>Main Articles</subject><subject>Male</subject><subject>Normal distribution</subject><subject>Otoacoustic Emissions, Spontaneous - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Signal-To-Noise Ratio</subject><subject>Vitamin A</subject><subject>Vitamin A - pharmacology</subject><subject>Vitamins - pharmacology</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1Lw0AQhhdRbK3-AC8S8OIlut-bPRZRKxQV1HPY7G7qlnzUbFLNv3djq4gic5gZ5pl3hheAYwTPEUTi4hFCjDFiCHEIoZR4B4yRoEnMKIe7YDyM42E-AgfeLwODBMT7YIQFlIwxNAazh8aubdW6uorqPFqEUpVOu9C1Id5D2fbRm2tfortYadv2he59a11lI1WZaO0Gvoqmh2AvV4W3R9s8Ac_XV0-Xs3h-f3N7OZ3HmmLUxkIbljFhKNcYEiqzjDBpuM204ZopjomBSlBJlFSEIouUlDQxRtlE5ZxaMgFnG91VU7921rdp6by2RaEqW3c-RSIhhMgEi4Ce_kKXdddU4btPCnPCIQkU2lC6qb1vbJ6uGleqpk8RTAeb0z82h52TrXKXldZ8b3z5GgCyFVVl1jizsD9u_yv7AZslhkE</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Aladag, I</creator><creator>Guven, M</creator><creator>Songu, M</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>201605</creationdate><title>Prevention of gentamicin ototoxicity with N-acetylcysteine and vitamin A</title><author>Aladag, I ; Guven, M ; Songu, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-7cd5b57d46c20349bb359d6ebcd6c5a623d0a7493a9a341e1a9948ddae8af64e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acetylcysteine - pharmacology</topic><topic>Acoustics</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - toxicity</topic><topic>Antibiotics</topic><topic>Apoptosis</topic><topic>Eardrum</topic><topic>Ears & hearing</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Gentamicins - toxicity</topic><topic>Hearing - drug effects</topic><topic>Hearing loss</topic><topic>Hearing Loss - chemically induced</topic><topic>Hearing Loss - prevention & control</topic><topic>Hearing protection</topic><topic>Lipid peroxidation</topic><topic>Main Articles</topic><topic>Male</topic><topic>Normal distribution</topic><topic>Otoacoustic Emissions, Spontaneous - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Signal-To-Noise Ratio</topic><topic>Vitamin A</topic><topic>Vitamin A - pharmacology</topic><topic>Vitamins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aladag, I</creatorcontrib><creatorcontrib>Guven, M</creatorcontrib><creatorcontrib>Songu, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aladag, I</au><au>Guven, M</au><au>Songu, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of gentamicin ototoxicity with N-acetylcysteine and vitamin A</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>2016-05</date><risdate>2016</risdate><volume>130</volume><issue>5</issue><spage>440</spage><epage>446</epage><pages>440-446</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><coden>JLOTAX</coden><abstract>To investigate the use of systemic N-acetylcysteine and vitamin A in the prevention of gentamicin ototoxicity in rats.
Forty-two Wistar rats were divided into four groups according to treatment: intratympanic saline, intratympanic gentamicin, intraperitoneal vitamin A after intratympanic gentamicin, and intraperitoneal N-acetylcysteine after intratympanic gentamicin. Signal-to-noise ratio and distortion product otoacoustic emissions were evaluated in all groups.
N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 2, 3, 4 and 6 kHz, as determined by the distortion product otoacoustic emission measurements. According to the signal-to-noise measurements, N-acetylcysteine had a significant protective effect at 1.5, 2, 3, 4, 6 and 8 kHz, whilst vitamin A had a significant protective effect at 3, 6 and 8 kHz.
Gentamicin-induced hearing loss in rats may be prevented by the concomitant use of vitamin A and N-acetylcysteine. Specifically, N-acetylcysteine appeared to have a more protective effect than vitamin A for a greater range of noise frequencies.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>27095551</pmid><doi>10.1017/S0022215116000992</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of laryngology and otology, 2016-05, Vol.130 (5), p.440-446 |
| issn | 0022-2151 1748-5460 |
| language | eng |
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| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Acetylcysteine - pharmacology Acoustics Animals Anti-Bacterial Agents - toxicity Antibiotics Apoptosis Eardrum Ears & hearing Free Radical Scavengers - pharmacology Gentamicins - toxicity Hearing - drug effects Hearing loss Hearing Loss - chemically induced Hearing Loss - prevention & control Hearing protection Lipid peroxidation Main Articles Male Normal distribution Otoacoustic Emissions, Spontaneous - drug effects Rats Rats, Wistar Signal-To-Noise Ratio Vitamin A Vitamin A - pharmacology Vitamins - pharmacology |
| title | Prevention of gentamicin ototoxicity with N-acetylcysteine and vitamin A |
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