Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss
To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time. Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 he...
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| Veröffentlicht in: | Journal of laryngology and otology 2016-05, Vol.130 (5), p.447-452 |
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| creator | Dinc, M E Ulusoy, S Is, A Ayan, N N Avincsal, M O Bicer, C Erel, O |
| description | To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time.
Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects.
Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls (p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002).
The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients. |
| doi_str_mv | 10.1017/S002221511600092X |
| format | Article |
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Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects.
Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls (p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002).
The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S002221511600092X</identifier><identifier>PMID: 27048937</identifier><identifier>CODEN: JLOTAX</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Audiometry ; Audiometry, Pure-Tone ; Blood tests ; Case-Control Studies ; Disease ; Disulfides - blood ; Female ; Hearing loss ; Hearing Loss, Sudden - blood ; Hearing Loss, Sudden - physiopathology ; Hearing protection ; Homeostasis ; Humans ; Main Articles ; Male ; Males ; Middle Aged ; Oxidative Stress ; Prospective Studies ; Sulfhydryl Compounds - blood</subject><ispartof>Journal of laryngology and otology, 2016-05, Vol.130 (5), p.447-452</ispartof><rights>Copyright © JLO (1984) Limited 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-65761c6ce8cb2ed696f9b71c1aa0b0588635b8e0ab29ab2286cab31f70ea425e3</citedby><cites>FETCH-LOGICAL-c373t-65761c6ce8cb2ed696f9b71c1aa0b0588635b8e0ab29ab2286cab31f70ea425e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S002221511600092X/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27048937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dinc, M E</creatorcontrib><creatorcontrib>Ulusoy, S</creatorcontrib><creatorcontrib>Is, A</creatorcontrib><creatorcontrib>Ayan, N N</creatorcontrib><creatorcontrib>Avincsal, M O</creatorcontrib><creatorcontrib>Bicer, C</creatorcontrib><creatorcontrib>Erel, O</creatorcontrib><title>Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time.
Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects.
Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls (p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002).
The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.</description><subject>Adult</subject><subject>Audiometry</subject><subject>Audiometry, Pure-Tone</subject><subject>Blood tests</subject><subject>Case-Control Studies</subject><subject>Disease</subject><subject>Disulfides - blood</subject><subject>Female</subject><subject>Hearing loss</subject><subject>Hearing Loss, Sudden - blood</subject><subject>Hearing Loss, Sudden - physiopathology</subject><subject>Hearing protection</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Main Articles</subject><subject>Male</subject><subject>Males</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>Prospective Studies</subject><subject>Sulfhydryl Compounds - blood</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kVFLHDEQx0NR6mn7AfpSAr70ZWsmuU12H4vYKgg-qODbkk1mvRy7mzOzK_rtzdVrKRYhwwT-v_lPJsPYFxDfQYA5uRZCSgklgBZC1PLuA1uAWVZFudRijy22crHVD9gh0TozYIT8yA6kEcuqVmbB1jerEPsTH2juN6vgka_igJEmS4G4zYeP8RF7HkYfnJ1i4rHj8Sl4O4VH5DQlJMoqp9l7zAlHiimMOCfb8xXafL_nfST6xPY72xN-3uUjdvvz7Ob0vLi8-nVx-uOycMqoqdCl0eC0w8q1Er2udVe3BhxYK1pRVpVWZVuhsK2sc8hKO9sq6IxAu5QlqiP27dV3k-LDjDQ1QyCHfW9HjDM1YCqlVA0gMnr8Bl3HOY35db8pqZWGOlPwSrmUx0jYNZsUBpueGxDNdhHNf4vINV93znM7oP9b8efnM6B2pnZoU_D3-E_vd21fALc8k5s</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Dinc, M E</creator><creator>Ulusoy, S</creator><creator>Is, A</creator><creator>Ayan, N N</creator><creator>Avincsal, M O</creator><creator>Bicer, C</creator><creator>Erel, O</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>201605</creationdate><title>Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss</title><author>Dinc, M E ; Ulusoy, S ; Is, A ; Ayan, N N ; Avincsal, M O ; Bicer, C ; Erel, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-65761c6ce8cb2ed696f9b71c1aa0b0588635b8e0ab29ab2286cab31f70ea425e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Audiometry</topic><topic>Audiometry, Pure-Tone</topic><topic>Blood tests</topic><topic>Case-Control Studies</topic><topic>Disease</topic><topic>Disulfides - blood</topic><topic>Female</topic><topic>Hearing loss</topic><topic>Hearing Loss, Sudden - blood</topic><topic>Hearing Loss, Sudden - physiopathology</topic><topic>Hearing protection</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Main Articles</topic><topic>Male</topic><topic>Males</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>Prospective Studies</topic><topic>Sulfhydryl Compounds - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dinc, M E</creatorcontrib><creatorcontrib>Ulusoy, S</creatorcontrib><creatorcontrib>Is, A</creatorcontrib><creatorcontrib>Ayan, N N</creatorcontrib><creatorcontrib>Avincsal, M O</creatorcontrib><creatorcontrib>Bicer, C</creatorcontrib><creatorcontrib>Erel, O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dinc, M E</au><au>Ulusoy, S</au><au>Is, A</au><au>Ayan, N N</au><au>Avincsal, M O</au><au>Bicer, C</au><au>Erel, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>2016-05</date><risdate>2016</risdate><volume>130</volume><issue>5</issue><spage>447</spage><epage>452</epage><pages>447-452</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><coden>JLOTAX</coden><abstract>To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time.
Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects.
Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls (p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002).
The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>27048937</pmid><doi>10.1017/S002221511600092X</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of laryngology and otology, 2016-05, Vol.130 (5), p.447-452 |
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| language | eng |
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| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Adult Audiometry Audiometry, Pure-Tone Blood tests Case-Control Studies Disease Disulfides - blood Female Hearing loss Hearing Loss, Sudden - blood Hearing Loss, Sudden - physiopathology Hearing protection Homeostasis Humans Main Articles Male Males Middle Aged Oxidative Stress Prospective Studies Sulfhydryl Compounds - blood |
| title | Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss |
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