Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response

The integrated stress response comprises multiple signaling pathways for detecting and responding to cellular stress that converge at a single event—the phosphorylation of Ser51 on the α‐subunit of eukaryotic translation initiation factor 2 (eIF2α). Phosphorylation of eIF2α (eIF2α‐P) results in atte...

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Veröffentlicht in:	ChemMedChem 2016-04, Vol.11 (8), p.870-880
Hauptverfasser:	Hearn, Brian R., Jaishankar, Priyadarshini, Sidrauski, Carmela, Tsai, Jordan C., Vedantham, Punitha, Fontaine, Shaun D., Walter, Peter, Renslo, Adam R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug Eukaryotic Initiation Factor-2 - agonists Eukaryotic Initiation Factor-2 - chemistry Eukaryotic Initiation Factor-2 - metabolism Glycolates - chemical synthesis Glycolates - chemistry Glycolates - pharmacology HEK293 Cells Humans integrated stress response ISRIB Molecular Structure Phosphorylation Phosphorylation - drug effects Protein Binding - drug effects Protein synthesis protein-protein interactions Proteins Stress response Stress, Physiological - drug effects Structure-Activity Relationship structure-activity relationships unfolded protein response
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