Expression of miRNA-26b in the diagnosis and prognosis of patients with non-small-cell lung cancer
To investigate the correlation between miR-26b and non-small-cell lung cancer (NSCLC). NSCLC tissues and normal lung tissues that were more than 7 cm adjacent from tumor were collected from 154 NSCLC patients. Additionally, 63 normal specimens from benign lung disease were selected as the control gr...
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| Veröffentlicht in: | Future oncology (London, England) England), 2016-05, Vol.12 (9), p.1105-1115 |
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| creator | Jiang, Li-Peng Zhu, Zhi-Tu He, Chun-Yan |
| description | To investigate the correlation between miR-26b and non-small-cell lung cancer (NSCLC).
NSCLC tissues and normal lung tissues that were more than 7 cm adjacent from tumor were collected from 154 NSCLC patients. Additionally, 63 normal specimens from benign lung disease were selected as the control group. Real-time fluorescent quantitative PCR was used to detect miR-26b expression in tissues.
miR-26b expression in NSCLC tissues was significantly lower than in other two types of tissues. Receiver operating characteristic curve analysis showed that the area under the curve was 0.856 with sensitivity and specificity of 79.9 and 79.4%, respectively. miR-26b expression was a risk factor for poor prognosis of NSCLC.
The expression of miR-26b is downregulated in NSCLC tissues, and it might be useful in the diagnosis and prognosis of NSCLC patients. |
| doi_str_mv | 10.2217/fon.16.21 |
| format | Article |
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NSCLC tissues and normal lung tissues that were more than 7 cm adjacent from tumor were collected from 154 NSCLC patients. Additionally, 63 normal specimens from benign lung disease were selected as the control group. Real-time fluorescent quantitative PCR was used to detect miR-26b expression in tissues.
miR-26b expression in NSCLC tissues was significantly lower than in other two types of tissues. Receiver operating characteristic curve analysis showed that the area under the curve was 0.856 with sensitivity and specificity of 79.9 and 79.4%, respectively. miR-26b expression was a risk factor for poor prognosis of NSCLC.
The expression of miR-26b is downregulated in NSCLC tissues, and it might be useful in the diagnosis and prognosis of NSCLC patients.</description><identifier>ISSN: 1479-6694</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon.16.21</identifier><identifier>PMID: 27033050</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Biomarkers, Tumor - genetics ; Breast cancer ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - diagnosis ; Carcinoma, Non-Small-Cell Lung - genetics ; Chemotherapy ; Classification ; diagnosis ; Disease ; Female ; Gene expression ; Gene Expression Profiling - methods ; Gene Expression Regulation, Neoplastic - genetics ; Humans ; Lung - pathology ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - genetics ; Male ; Medical prognosis ; Metastasis ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; miR-26b ; miRNAs ; non-small-cell lung cancer ; Patients ; Prognosis ; Radiation therapy ; Tumors</subject><ispartof>Future oncology (London, England), 2016-05, Vol.12 (9), p.1105-1115</ispartof><rights>Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd May 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-3970076b93d1c788a05a1b2bc49ecf3e384b2081b562761ba97de55998e73cef3</citedby><cites>FETCH-LOGICAL-c359t-3970076b93d1c788a05a1b2bc49ecf3e384b2081b562761ba97de55998e73cef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27033050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Li-Peng</creatorcontrib><creatorcontrib>Zhu, Zhi-Tu</creatorcontrib><creatorcontrib>He, Chun-Yan</creatorcontrib><title>Expression of miRNA-26b in the diagnosis and prognosis of patients with non-small-cell lung cancer</title><title>Future oncology (London, England)</title><addtitle>Future Oncol</addtitle><description>To investigate the correlation between miR-26b and non-small-cell lung cancer (NSCLC).
NSCLC tissues and normal lung tissues that were more than 7 cm adjacent from tumor were collected from 154 NSCLC patients. Additionally, 63 normal specimens from benign lung disease were selected as the control group. Real-time fluorescent quantitative PCR was used to detect miR-26b expression in tissues.
miR-26b expression in NSCLC tissues was significantly lower than in other two types of tissues. Receiver operating characteristic curve analysis showed that the area under the curve was 0.856 with sensitivity and specificity of 79.9 and 79.4%, respectively. miR-26b expression was a risk factor for poor prognosis of NSCLC.
The expression of miR-26b is downregulated in NSCLC tissues, and it might be useful in the diagnosis and prognosis of NSCLC patients.</description><subject>Biomarkers, Tumor - genetics</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Chemotherapy</subject><subject>Classification</subject><subject>diagnosis</subject><subject>Disease</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humans</subject><subject>Lung - pathology</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miR-26b</subject><subject>miRNAs</subject><subject>non-small-cell lung cancer</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Tumors</subject><issn>1479-6694</issn><issn>1744-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkE1LHTEUhoNY1KoL_0AJuGkXc83H5GspolaQFoquQ5I5o5GZ5HYyg_bfN5d7dVG6OufAc15eHoTOKFkxRtVFn9OKyhWje-iIqrZtNCd0v-6tMo2Upj1En0t5IaRVXJADdMgU4ZwIcoT89dt6glJiTjj3eIy_flw2THocE56fAXfRPaVcYsEudXg95d1V2bWbI6S54Nc4P-OUU1NGNwxNgGHAw5KecHApwHSCPvVuKHC6m8fo8eb64ep7c__z9u7q8r4JXJi54UYRoqQ3vKNBae2IcNQzH1oDoefAdesZ0dQLyZSk3hnVgRDGaFA8QM-P0ddtbm35e4Ey2zGWTRmXIC_FUqU555pqWdHzf9CXvEyptrOMKcG4FmZDfdtSYcqlTNDb9RRHN_2xlNiNeFvFWyoto5X9sktc_AjdB_luugJiC_TLvFTjoboLYLdX_YghJvhP8F8f0Y-g</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Jiang, Li-Peng</creator><creator>Zhu, Zhi-Tu</creator><creator>He, Chun-Yan</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Expression of miRNA-26b in the diagnosis and prognosis of patients with non-small-cell lung cancer</title><author>Jiang, Li-Peng ; Zhu, Zhi-Tu ; He, Chun-Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-3970076b93d1c788a05a1b2bc49ecf3e384b2081b562761ba97de55998e73cef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biomarkers, Tumor - genetics</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnosis</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Chemotherapy</topic><topic>Classification</topic><topic>diagnosis</topic><topic>Disease</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Humans</topic><topic>Lung - pathology</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miR-26b</topic><topic>miRNAs</topic><topic>non-small-cell lung cancer</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Li-Peng</creatorcontrib><creatorcontrib>Zhu, Zhi-Tu</creatorcontrib><creatorcontrib>He, Chun-Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Future oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Li-Peng</au><au>Zhu, Zhi-Tu</au><au>He, Chun-Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of miRNA-26b in the diagnosis and prognosis of patients with non-small-cell lung cancer</atitle><jtitle>Future oncology (London, England)</jtitle><addtitle>Future Oncol</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>12</volume><issue>9</issue><spage>1105</spage><epage>1115</epage><pages>1105-1115</pages><issn>1479-6694</issn><eissn>1744-8301</eissn><abstract>To investigate the correlation between miR-26b and non-small-cell lung cancer (NSCLC).
NSCLC tissues and normal lung tissues that were more than 7 cm adjacent from tumor were collected from 154 NSCLC patients. Additionally, 63 normal specimens from benign lung disease were selected as the control group. Real-time fluorescent quantitative PCR was used to detect miR-26b expression in tissues.
miR-26b expression in NSCLC tissues was significantly lower than in other two types of tissues. Receiver operating characteristic curve analysis showed that the area under the curve was 0.856 with sensitivity and specificity of 79.9 and 79.4%, respectively. miR-26b expression was a risk factor for poor prognosis of NSCLC.
The expression of miR-26b is downregulated in NSCLC tissues, and it might be useful in the diagnosis and prognosis of NSCLC patients.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>27033050</pmid><doi>10.2217/fon.16.21</doi><tpages>11</tpages></addata></record> |
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| subjects | Biomarkers, Tumor - genetics Breast cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Chemotherapy Classification diagnosis Disease Female Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Humans Lung - pathology Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - genetics Male Medical prognosis Metastasis MicroRNAs MicroRNAs - genetics Middle Aged miR-26b miRNAs non-small-cell lung cancer Patients Prognosis Radiation therapy Tumors |
| title | Expression of miRNA-26b in the diagnosis and prognosis of patients with non-small-cell lung cancer |
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