Low-dose adenoviral immunotherapy of rat hepatocellular carcinoma using single-chain interleukin-12

Generation of antitumor immunity by adenoviral gene transfer of interleukin-12 (IL-12) is a very promising concept in cancer gene therapy. Systemically, IL-12 has provoked toxic side effects at therapeutically relevant doses. Native IL-12 lacks effectiveness in clinical trials even when expressed in...

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Veröffentlicht in:	Human gene therapy 2005-03, Vol.16 (3), p.307-317
Hauptverfasser:	WAEHLER, Reinhard, ITTRICH, Harald, MUELLER, Lars, KRUPSKI, Gerrit, AMEIS, Detlev, SCHNIEDERS, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Cell Line Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene therapy Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Genetic Vectors - therapeutic use Health. Pharmaceutical industry Histological Techniques Immunotherapy - methods Industrial applications and implications. Economical aspects Interleukin-12 - blood Interleukin-12 - genetics Interleukin-12 - therapeutic use Liver Neoplasms, Experimental - immunology Liver Neoplasms, Experimental - pathology Liver Neoplasms, Experimental - therapy Liver. Biliary tract. Portal circulation. Exocrine pancreas Magnetic Resonance Imaging Medical sciences Mice Rats Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumors
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