CD45 Negatively Regulates Monocytic Cell Differentiation by Inhibiting Phorbol 12-Myristate 13-Acetate-dependent Activation and Tyrosine Phosphorylation of Protein Kinase Cδ

The protein-tyrosine phosphatase CD45 is expressed on all monocytic cells, but its function in these cells is not well defined. Here we report that CD45 negatively regulates monocyte differentiation by inhibiting phorbol 12-myristate 13-acetate (PMA)-dependent activation of protein kinase C (PKC) δ....

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Veröffentlicht in:	The Journal of biological chemistry 2001-03, Vol.276 (13), p.10212-10217
Hauptverfasser:	Deszo, Eric L., Brake, Danett K., Cengel, Keith A., Kelley, Keith W., Freund, Gregory G.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD45 antigen phorbol esters tyrosine U937 cells
Online-Zugang:	Volltext
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