Nanobiohybrids as delivery vehicles for camptothecin

A novel method of delivering non-ionic, poorly water-soluble drugs such as campthothecin was developed. Camptothecin was first incorporated into micelles derived from negatively charged surfactants. The negatively charged micelles were then encapsulated in nanoparticles of magnesium–aluminum layered...

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Veröffentlicht in:	Journal of controlled release 2004-03, Vol.95 (3), p.501-514
Hauptverfasser:	Tyner, Katherine M, Schiffman, Scott R, Giannelis, Emmanuel P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum - chemistry Animals Biological and medical sciences Camptothecin Camptothecin - adverse effects Camptothecin - chemistry Carmine - chemistry Cell Line, Tumor Controlled release Drug Carriers - chemistry Drug Carriers - pharmacokinetics General pharmacology Hydrogen-Ion Concentration Hydroxides - chemistry Ion Exchange Layered double hydroxide Magnesium - chemistry Medical sciences Micelles Models, Chemical Nanobiohybrid Nanotechnology - methods Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Sodium Cholate - chemistry Solubility Surface-Active Agents Time Factors
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