In vitro study of GDNF release from biodegradable PLGA microspheres

Glial cell line-derived neurotrophic factor (GDNF) is a protein with potent trophic actions on dopaminergic neurons, which is under investigation as a therapeutic agent for the treatment of neurodegenerative disorders, including Parkinson's disease. The aim of this work was to develop GDNF-load...

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Veröffentlicht in:	Journal of controlled release 2004-03, Vol.95 (3), p.463-475
Hauptverfasser:	Aubert-Pouëssel, Anne, Venier-Julienne, Marie-Claire, Clavreul, Anne, Sergent, Michelle, Jollivet, Christophe, Montero-Menei, Claudia N., Garcion, Emmanuel, Bibby, David C., Menei, Philippe, Benoit, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Animals Biodegradation, Environmental - drug effects Biological and medical sciences Chemistry, Pharmaceutical - methods Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacology Drug Evaluation, Preclinical - methods Drug Stability Enzyme-Linked Immunosorbent Assay - methods Experimental design GDNF General pharmacology Glial Cell Line-Derived Neurotrophic Factor Iodine Radioisotopes Lactic Acid - administration & dosage Lactic Acid - chemistry Materials Testing - methods Medical sciences Microspheres Nerve Growth Factors - chemistry Nerve Growth Factors - pharmacokinetics Nerve Growth Factors - therapeutic use Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(lactic-co-glycolic acid) Polyglycolic Acid - administration & dosage Polyglycolic Acid - chemistry Polymers - administration & dosage Polymers - chemistry Polypropylenes - chemistry Stabilization Technology, Pharmaceutical - methods Time Factors
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