Impulsive-Aggressive Traits, Serotonin Function, and Alcohol-Enhanced Aggression
Although alcohol consumption is involved in most acts of violence, most people do not become violent when they drink. Individuals also respond differently to alcohol on laboratory measures of aggression. The objective of this study was to determine whether individual differences in the effects of al...
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| Veröffentlicht in: | Journal of clinical pharmacology 2005-01, Vol.45 (1), p.94-100 |
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| creator | Fulwiler, Carl Eckstine, Joy Kalsy, Sapna |
| description | Although alcohol consumption is involved in most acts of violence, most people do not become violent when they drink. Individuals also respond differently to alcohol on laboratory measures of aggression. The objective of this study was to determine whether individual differences in the effects of alcohol on a laboratory measure of aggression are related to specific personality traits and/or serotonin function, as measured by prolactin response to pharmacochallenge. Psychometric scales for impulsiveness, aggression, and anger, as well as a probe for suspiciousness, were administered to 10 healthy male social drinkers. Trait serotonin function was determined by citalopram challenge. The effect of alcohol on the Point Subtraction Aggression Paradigm was determined by comparing aggression scores with and without 1 g/kg alcohol. Impulsivity scores were significantly correlated with the change in aggressive responding after alcohol. Aggression, anger, and suspiciousness scores were not. Prolactin response did not predict the effect of alcohol on aggressive responding. The results suggest that trait impulsiveness may mediate the effects of alcohol on aggression in normal males. |
| doi_str_mv | 10.1177/0091270004270457 |
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Individuals also respond differently to alcohol on laboratory measures of aggression. The objective of this study was to determine whether individual differences in the effects of alcohol on a laboratory measure of aggression are related to specific personality traits and/or serotonin function, as measured by prolactin response to pharmacochallenge. Psychometric scales for impulsiveness, aggression, and anger, as well as a probe for suspiciousness, were administered to 10 healthy male social drinkers. Trait serotonin function was determined by citalopram challenge. The effect of alcohol on the Point Subtraction Aggression Paradigm was determined by comparing aggression scores with and without 1 g/kg alcohol. Impulsivity scores were significantly correlated with the change in aggressive responding after alcohol. Aggression, anger, and suspiciousness scores were not. Prolactin response did not predict the effect of alcohol on aggressive responding. 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Individuals also respond differently to alcohol on laboratory measures of aggression. The objective of this study was to determine whether individual differences in the effects of alcohol on a laboratory measure of aggression are related to specific personality traits and/or serotonin function, as measured by prolactin response to pharmacochallenge. Psychometric scales for impulsiveness, aggression, and anger, as well as a probe for suspiciousness, were administered to 10 healthy male social drinkers. Trait serotonin function was determined by citalopram challenge. The effect of alcohol on the Point Subtraction Aggression Paradigm was determined by comparing aggression scores with and without 1 g/kg alcohol. Impulsivity scores were significantly correlated with the change in aggressive responding after alcohol. Aggression, anger, and suspiciousness scores were not. Prolactin response did not predict the effect of alcohol on aggressive responding. The results suggest that trait impulsiveness may mediate the effects of alcohol on aggression in normal males.</description><subject>Adult</subject><subject>aggression</subject><subject>Aggression - drug effects</subject><subject>Aggression - psychology</subject><subject>Aggressiveness (Psychology)</subject><subject>Alcohol</subject><subject>Alcohol Drinking - blood</subject><subject>Alcohol Drinking - psychology</subject><subject>Drinking of alcoholic beverages</subject><subject>Ethanol - administration & dosage</subject><subject>Humans</subject><subject>Impulsive Behavior - blood</subject><subject>Impulsive Behavior - psychology</subject><subject>impulsivity</subject><subject>Male</subject><subject>personality</subject><subject>Personality Inventory</subject><subject>Physiological aspects</subject><subject>Prolactin - blood</subject><subject>Psychological aspects</subject><subject>Serotonin</subject><subject>Serotonin - blood</subject><subject>Serotonin Uptake Inhibitors - pharmacology</subject><subject>temperament</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhiMEokvhzgnlxKkp48QfyXFZdbeFCipRxNFynMluqGNv7YTSf49DIpC4IMsee-Z9Xo0nSV4TOCdEiHcAFckFANB4UiaeJCvCWJ5RDvRpsprK2VQ_SV6E8B2AcMrI8-SEMA6kJLBKbq7642hC9wOz9X7vMUzX9Narbghn6Rf0bnC2s-l2tHronD1LlW3StdHu4Ex2YQ_KaoyJhXX2ZfKsVSbgqyWeJl-3F7eby-z68-5qs77ONOUcMlUgCM1FK-oKS8CipHlTa1HXtGpzUqqKVaxQwKDUpULRtKxueNUg1kIVoIvT5O3se_TufsQwyL4LGo1RFt0YJBFlTkvgUXg-C_fKoOxs6wavdFwN9p12Ftsu5teEgqhoWUwAzID2LgSPrTz6rlf-URKQ09jlv2OPyJulmbHusfkLLHOOAjoLHpwZ0Ic7Mz6glwdUZjhEv2gV_bIc4odJfGVx_8b4gsUeH__bh_ywubkkwEgEsxnswoA__4DK30kuCsHkt087ScnuIxS7rXxf_AKFAaoy</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Fulwiler, Carl</creator><creator>Eckstine, Joy</creator><creator>Kalsy, Sapna</creator><general>Blackwell Publishing Ltd</general><general>SAGE Publications</general><general>Sage Publications, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200501</creationdate><title>Impulsive-Aggressive Traits, Serotonin Function, and Alcohol-Enhanced Aggression</title><author>Fulwiler, Carl ; Eckstine, Joy ; Kalsy, Sapna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4660-a3e07c67f7b9e80e3842dbc7bb49f218a95953a0508c8ae7df5bd69deeb7a30c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>aggression</topic><topic>Aggression - drug effects</topic><topic>Aggression - psychology</topic><topic>Aggressiveness (Psychology)</topic><topic>Alcohol</topic><topic>Alcohol Drinking - blood</topic><topic>Alcohol Drinking - psychology</topic><topic>Drinking of alcoholic beverages</topic><topic>Ethanol - administration & dosage</topic><topic>Humans</topic><topic>Impulsive Behavior - blood</topic><topic>Impulsive Behavior - psychology</topic><topic>impulsivity</topic><topic>Male</topic><topic>personality</topic><topic>Personality Inventory</topic><topic>Physiological aspects</topic><topic>Prolactin - blood</topic><topic>Psychological aspects</topic><topic>Serotonin</topic><topic>Serotonin - blood</topic><topic>Serotonin Uptake Inhibitors - pharmacology</topic><topic>temperament</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fulwiler, Carl</creatorcontrib><creatorcontrib>Eckstine, Joy</creatorcontrib><creatorcontrib>Kalsy, Sapna</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fulwiler, Carl</au><au>Eckstine, Joy</au><au>Kalsy, Sapna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impulsive-Aggressive Traits, Serotonin Function, and Alcohol-Enhanced Aggression</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>2005-01</date><risdate>2005</risdate><volume>45</volume><issue>1</issue><spage>94</spage><epage>100</epage><pages>94-100</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><abstract>Although alcohol consumption is involved in most acts of violence, most people do not become violent when they drink. Individuals also respond differently to alcohol on laboratory measures of aggression. The objective of this study was to determine whether individual differences in the effects of alcohol on a laboratory measure of aggression are related to specific personality traits and/or serotonin function, as measured by prolactin response to pharmacochallenge. Psychometric scales for impulsiveness, aggression, and anger, as well as a probe for suspiciousness, were administered to 10 healthy male social drinkers. Trait serotonin function was determined by citalopram challenge. The effect of alcohol on the Point Subtraction Aggression Paradigm was determined by comparing aggression scores with and without 1 g/kg alcohol. Impulsivity scores were significantly correlated with the change in aggressive responding after alcohol. Aggression, anger, and suspiciousness scores were not. Prolactin response did not predict the effect of alcohol on aggressive responding. The results suggest that trait impulsiveness may mediate the effects of alcohol on aggression in normal males.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15601810</pmid><doi>10.1177/0091270004270457</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult aggression Aggression - drug effects Aggression - psychology Aggressiveness (Psychology) Alcohol Alcohol Drinking - blood Alcohol Drinking - psychology Drinking of alcoholic beverages Ethanol - administration & dosage Humans Impulsive Behavior - blood Impulsive Behavior - psychology impulsivity Male personality Personality Inventory Physiological aspects Prolactin - blood Psychological aspects Serotonin Serotonin - blood Serotonin Uptake Inhibitors - pharmacology temperament |
| title | Impulsive-Aggressive Traits, Serotonin Function, and Alcohol-Enhanced Aggression |
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