Sequential Inactivation of rdxA (HP0954) and frxA (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in Helicobacter pylori

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Veröffentlicht in:	Journal of Bacteriology 2000-09, Vol.182 (18), p.5082-5090
Hauptverfasser:	Jeong, J Y, Mukhopadhyay, A K, Dailidiene, D, Wang, Y, Velapatiño, B, Gilman, R H, Parkinson, A J, Nair, G B, Wong, B C, Lam, S K, Mistry, R, Segal, I, Yuan, Y, Gao, H, Alarcon, T, Brea, M L, Ito, Y, Kersulyte, D, Lee, H K, Gong, Y, Goodwin, A, Hoffman, P S, Berg, D E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Anti-Bacterial Agents - pharmacology Bacteria Bacteriology Chloramphenicol - pharmacology Drug Resistance, Microbial - genetics frxA gene Genes Helicobacter pylori Helicobacter pylori - drug effects Helicobacter pylori - enzymology Helicobacter pylori - genetics Helicobacter pylori - isolation & purification Humans metronidazole Metronidazole - pharmacology Microbial Sensitivity Tests Mutagenesis Mutagenesis, Site-Directed nitroreductase Nitroreductases - genetics Nitroreductases - metabolism Population Genetics and Evolution rdxA gene Sequence Deletion
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