Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control
Abstract Anomalies in behavioral correlates of attentional processing and related brain activity are crucial correlates of schizophrenia and associated with familial risk for this brain disorder. However, it is not clear how brain functional connectivity during attentional processes is key for schiz...
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| Veröffentlicht in: | Schizophrenia research 2016-05, Vol.173 (1-2), p.23-29 |
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| creator | Antonucci, Linda A Taurisano, Paolo Fazio, Leonardo Gelao, Barbara Romano, Raffaella Quarto, Tiziana Porcelli, Annamaria Mancini, Marina Di Giorgio, Annabella Caforio, Grazia Pergola, Giulio Popolizio, Teresa Bertolino, Alessandro Blasi, Giuseppe |
| description | Abstract Anomalies in behavioral correlates of attentional processing and related brain activity are crucial correlates of schizophrenia and associated with familial risk for this brain disorder. However, it is not clear how brain functional connectivity during attentional processes is key for schizophrenia and linked with trait vs. state related variables. To address this issue, we investigated patterns of functional connections during attentional control in healthy siblings of patients with schizophrenia, who share with probands genetic features but not variables related to the state of the disorder. 356 controls, 55 patients with schizophrenia on stable treatment with antipsychotics and 40 healthy siblings of patients with this brain disorder underwent the Variable Attentional Control (VAC) task during fMRI. Independent Component Analysis (ICA) is allowed to identify independent components (IC) of BOLD signal recorded during task performance. Results indicated reduced connectivity strength in patients with schizophrenia as well as in their healthy siblings in left thalamus within an attentional control component and greater connectivity in right medial prefrontal cortex (PFC) within the so-called Default Mode Network (DMN) compared to healthy individuals. These results suggest a relationship between familial risk for schizophrenia and brain functional networks during attentional control, such that this biological phenotype may be considered a useful intermediate phenotype in order to link genes effects to aspects of the pathophysiology of this brain disorder. |
| doi_str_mv | 10.1016/j.schres.2016.03.014 |
| format | Article |
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However, it is not clear how brain functional connectivity during attentional processes is key for schizophrenia and linked with trait vs. state related variables. To address this issue, we investigated patterns of functional connections during attentional control in healthy siblings of patients with schizophrenia, who share with probands genetic features but not variables related to the state of the disorder. 356 controls, 55 patients with schizophrenia on stable treatment with antipsychotics and 40 healthy siblings of patients with this brain disorder underwent the Variable Attentional Control (VAC) task during fMRI. Independent Component Analysis (ICA) is allowed to identify independent components (IC) of BOLD signal recorded during task performance. Results indicated reduced connectivity strength in patients with schizophrenia as well as in their healthy siblings in left thalamus within an attentional control component and greater connectivity in right medial prefrontal cortex (PFC) within the so-called Default Mode Network (DMN) compared to healthy individuals. These results suggest a relationship between familial risk for schizophrenia and brain functional networks during attentional control, such that this biological phenotype may be considered a useful intermediate phenotype in order to link genes effects to aspects of the pathophysiology of this brain disorder.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2016.03.014</identifier><identifier>PMID: 27012899</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Analysis of Variance ; Attention - physiology ; Attentional control ; Brain Mapping ; Default mode network ; Family Health ; Female ; fMRI ; Humans ; Image Processing, Computer-Assisted ; Independent component analysis ; Magnetic Resonance Imaging ; Male ; Models, Neurological ; Oxygen - blood ; Prefrontal Cortex - diagnostic imaging ; Principal Component Analysis ; Psychiatric Status Rating Scales ; Psychiatry ; Schizophrenia ; Schizophrenia - diagnostic imaging ; Schizophrenia - genetics ; Schizophrenia - pathology ; Schizophrenia - physiopathology ; Thalamus ; Thalamus - diagnostic imaging ; Young Adult</subject><ispartof>Schizophrenia research, 2016-05, Vol.173 (1-2), p.23-29</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f9ff77ebd812c569b272ba76cee045d7870a4a48202cb86c540f13a0cd5c78c63</citedby><cites>FETCH-LOGICAL-c417t-f9ff77ebd812c569b272ba76cee045d7870a4a48202cb86c540f13a0cd5c78c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0920996416301074$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27012899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antonucci, Linda A</creatorcontrib><creatorcontrib>Taurisano, Paolo</creatorcontrib><creatorcontrib>Fazio, Leonardo</creatorcontrib><creatorcontrib>Gelao, Barbara</creatorcontrib><creatorcontrib>Romano, Raffaella</creatorcontrib><creatorcontrib>Quarto, Tiziana</creatorcontrib><creatorcontrib>Porcelli, Annamaria</creatorcontrib><creatorcontrib>Mancini, Marina</creatorcontrib><creatorcontrib>Di Giorgio, Annabella</creatorcontrib><creatorcontrib>Caforio, Grazia</creatorcontrib><creatorcontrib>Pergola, Giulio</creatorcontrib><creatorcontrib>Popolizio, Teresa</creatorcontrib><creatorcontrib>Bertolino, Alessandro</creatorcontrib><creatorcontrib>Blasi, Giuseppe</creatorcontrib><title>Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Abstract Anomalies in behavioral correlates of attentional processing and related brain activity are crucial correlates of schizophrenia and associated with familial risk for this brain disorder. However, it is not clear how brain functional connectivity during attentional processes is key for schizophrenia and linked with trait vs. state related variables. To address this issue, we investigated patterns of functional connections during attentional control in healthy siblings of patients with schizophrenia, who share with probands genetic features but not variables related to the state of the disorder. 356 controls, 55 patients with schizophrenia on stable treatment with antipsychotics and 40 healthy siblings of patients with this brain disorder underwent the Variable Attentional Control (VAC) task during fMRI. Independent Component Analysis (ICA) is allowed to identify independent components (IC) of BOLD signal recorded during task performance. Results indicated reduced connectivity strength in patients with schizophrenia as well as in their healthy siblings in left thalamus within an attentional control component and greater connectivity in right medial prefrontal cortex (PFC) within the so-called Default Mode Network (DMN) compared to healthy individuals. These results suggest a relationship between familial risk for schizophrenia and brain functional networks during attentional control, such that this biological phenotype may be considered a useful intermediate phenotype in order to link genes effects to aspects of the pathophysiology of this brain disorder.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Attention - physiology</subject><subject>Attentional control</subject><subject>Brain Mapping</subject><subject>Default mode network</subject><subject>Family Health</subject><subject>Female</subject><subject>fMRI</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Independent component analysis</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Models, Neurological</subject><subject>Oxygen - blood</subject><subject>Prefrontal Cortex - diagnostic imaging</subject><subject>Principal Component Analysis</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - pathology</subject><subject>Schizophrenia - physiopathology</subject><subject>Thalamus</subject><subject>Thalamus - diagnostic imaging</subject><subject>Young Adult</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstuFDEQtBCILIE_QMhHLjO0PQ_PXJCiiJcUiQPJ2fJ4bNYbr73YnqDlzn-nRxtA4pKTu-XqKnVVE_KaQc2A9e92ddbbZHLNsauhqYG1T8iGdaKpeAfjU7KBkUM1jn17Rl7kvAMA1oF4Ts64AMaHcdyQ3xc5R-1UcTHQaKlVe-ed8jS5fEttTBRV3K94QKngFP3pypaWrfKI01SFme7NvOIPydgUQ8HSLkGvfFjqGILB5s6VI52X5MJ3qkox4d9_SdG_JM-s8tm8enjPyc3HD9eXn6urr5--XF5cVbplolR2tFYIM80D47rrx4kLPinRa2Og7WYxCFCtagcOXE9Dr7sWLGsU6LnTYtB9c07enngPKf5YTC5y77I23qtg4pIlEwPnrB-bBqHtCapTzBmXk4fk9iodJQO5BiB38hSAXAOQ0EgMAMfePCgsEzrzd-iP4wh4fwIY3PPOmYQszgSNLiZ0Ss7RPabwP4H2Ljit_K05mryLS0JncReZuQT5bT2C9QZY3wAD0Tb3TI-xsw</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Antonucci, Linda A</creator><creator>Taurisano, Paolo</creator><creator>Fazio, Leonardo</creator><creator>Gelao, Barbara</creator><creator>Romano, Raffaella</creator><creator>Quarto, Tiziana</creator><creator>Porcelli, Annamaria</creator><creator>Mancini, Marina</creator><creator>Di Giorgio, Annabella</creator><creator>Caforio, Grazia</creator><creator>Pergola, Giulio</creator><creator>Popolizio, Teresa</creator><creator>Bertolino, Alessandro</creator><creator>Blasi, Giuseppe</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control</title><author>Antonucci, Linda A ; Taurisano, Paolo ; Fazio, Leonardo ; Gelao, Barbara ; Romano, Raffaella ; Quarto, Tiziana ; Porcelli, Annamaria ; Mancini, Marina ; Di Giorgio, Annabella ; Caforio, Grazia ; Pergola, Giulio ; Popolizio, Teresa ; Bertolino, Alessandro ; Blasi, Giuseppe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f9ff77ebd812c569b272ba76cee045d7870a4a48202cb86c540f13a0cd5c78c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Attention - physiology</topic><topic>Attentional control</topic><topic>Brain Mapping</topic><topic>Default mode network</topic><topic>Family Health</topic><topic>Female</topic><topic>fMRI</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Independent component analysis</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Models, Neurological</topic><topic>Oxygen - blood</topic><topic>Prefrontal Cortex - diagnostic imaging</topic><topic>Principal Component Analysis</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia - pathology</topic><topic>Schizophrenia - physiopathology</topic><topic>Thalamus</topic><topic>Thalamus - diagnostic imaging</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antonucci, Linda A</creatorcontrib><creatorcontrib>Taurisano, Paolo</creatorcontrib><creatorcontrib>Fazio, Leonardo</creatorcontrib><creatorcontrib>Gelao, Barbara</creatorcontrib><creatorcontrib>Romano, Raffaella</creatorcontrib><creatorcontrib>Quarto, Tiziana</creatorcontrib><creatorcontrib>Porcelli, Annamaria</creatorcontrib><creatorcontrib>Mancini, Marina</creatorcontrib><creatorcontrib>Di Giorgio, Annabella</creatorcontrib><creatorcontrib>Caforio, Grazia</creatorcontrib><creatorcontrib>Pergola, Giulio</creatorcontrib><creatorcontrib>Popolizio, Teresa</creatorcontrib><creatorcontrib>Bertolino, Alessandro</creatorcontrib><creatorcontrib>Blasi, Giuseppe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antonucci, Linda A</au><au>Taurisano, Paolo</au><au>Fazio, Leonardo</au><au>Gelao, Barbara</au><au>Romano, Raffaella</au><au>Quarto, Tiziana</au><au>Porcelli, Annamaria</au><au>Mancini, Marina</au><au>Di Giorgio, Annabella</au><au>Caforio, Grazia</au><au>Pergola, Giulio</au><au>Popolizio, Teresa</au><au>Bertolino, Alessandro</au><au>Blasi, Giuseppe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>173</volume><issue>1-2</issue><spage>23</spage><epage>29</epage><pages>23-29</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Abstract Anomalies in behavioral correlates of attentional processing and related brain activity are crucial correlates of schizophrenia and associated with familial risk for this brain disorder. However, it is not clear how brain functional connectivity during attentional processes is key for schizophrenia and linked with trait vs. state related variables. To address this issue, we investigated patterns of functional connections during attentional control in healthy siblings of patients with schizophrenia, who share with probands genetic features but not variables related to the state of the disorder. 356 controls, 55 patients with schizophrenia on stable treatment with antipsychotics and 40 healthy siblings of patients with this brain disorder underwent the Variable Attentional Control (VAC) task during fMRI. Independent Component Analysis (ICA) is allowed to identify independent components (IC) of BOLD signal recorded during task performance. Results indicated reduced connectivity strength in patients with schizophrenia as well as in their healthy siblings in left thalamus within an attentional control component and greater connectivity in right medial prefrontal cortex (PFC) within the so-called Default Mode Network (DMN) compared to healthy individuals. These results suggest a relationship between familial risk for schizophrenia and brain functional networks during attentional control, such that this biological phenotype may be considered a useful intermediate phenotype in order to link genes effects to aspects of the pathophysiology of this brain disorder.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27012899</pmid><doi>10.1016/j.schres.2016.03.014</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Analysis of Variance Attention - physiology Attentional control Brain Mapping Default mode network Family Health Female fMRI Humans Image Processing, Computer-Assisted Independent component analysis Magnetic Resonance Imaging Male Models, Neurological Oxygen - blood Prefrontal Cortex - diagnostic imaging Principal Component Analysis Psychiatric Status Rating Scales Psychiatry Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - genetics Schizophrenia - pathology Schizophrenia - physiopathology Thalamus Thalamus - diagnostic imaging Young Adult |
| title | Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control |
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