Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment
Abstract Plasma concentration of three methylated arginines, endogenous nitric oxide synthase inhibitors, is not studied in schizophrenic patients. The purpose of this study was to determine plasma concentrations of N G - monomethyl- l -arginine ( l -NMMA), N G , N G -dimethyl- l -arginine (ADMA), N...
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| Veröffentlicht in: | Psychiatry research 2016-04, Vol.238, p.203-210 |
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| creator | Nonaka-Hashida, Satoko Sekine, Masae Ozeki, Yuji Fujii, Kumiko Akiyama, Kazufumi Shimoda, Kazutaka Tsunoda, Makoto Katane, Masumi Saitoh, Yasuaki Miyamoto, Tetsuya Homma, Hiroshi |
| description | Abstract Plasma concentration of three methylated arginines, endogenous nitric oxide synthase inhibitors, is not studied in schizophrenic patients. The purpose of this study was to determine plasma concentrations of N G - monomethyl- l -arginine ( l -NMMA), N G , N G -dimethyl- l -arginine (ADMA), NG , NG’ -dimethyl- l -arginine (SDMA), and l -arginine in 56 male and 45 female schizophrenic patients undergoing antipsychotic drug treatment versus those of 39 male and 24 female healthy controls. Plasma concentrations of methylated arginines and l -arginine were measured using newly developed high performance liquid chromatography with fluorescence detection which we previously reported. Methylated arginine levels were slightly but significantly higher in schizophrenic patients. l -Arginine levels and the l -arginine/(ADMA+ l -NMMA) ratio were higher in schizophrenic patients than in healthy controls. It is considered that pharmacological treatment of schizophrenic patients may lower methylated arginine levels that are increased by the disease, and increase l -arginine levels, eliciting an improvement in nitric oxide (NO) bioavailability. |
| doi_str_mv | 10.1016/j.psychres.2016.02.029 |
| format | Article |
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The purpose of this study was to determine plasma concentrations of N G - monomethyl- l -arginine ( l -NMMA), N G , N G -dimethyl- l -arginine (ADMA), NG , NG’ -dimethyl- l -arginine (SDMA), and l -arginine in 56 male and 45 female schizophrenic patients undergoing antipsychotic drug treatment versus those of 39 male and 24 female healthy controls. Plasma concentrations of methylated arginines and l -arginine were measured using newly developed high performance liquid chromatography with fluorescence detection which we previously reported. Methylated arginine levels were slightly but significantly higher in schizophrenic patients. l -Arginine levels and the l -arginine/(ADMA+ l -NMMA) ratio were higher in schizophrenic patients than in healthy controls. It is considered that pharmacological treatment of schizophrenic patients may lower methylated arginine levels that are increased by the disease, and increase l -arginine levels, eliciting an improvement in nitric oxide (NO) bioavailability.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2016.02.029</identifier><identifier>PMID: 27086234</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>ADMA ; Adult ; Aged ; Aged, 80 and over ; Antipsychotic Agents - therapeutic use ; Arginine - analogs & derivatives ; Arginine - blood ; Female ; Humans ; L-arginine ; L-NMMA ; Male ; Middle Aged ; Nitric Oxide Synthase - antagonists & inhibitors ; NOS inhibitor ; omega-N-Methylarginine - blood ; Psychiatry ; Schizophrenia ; Schizophrenia - blood ; Schizophrenia - drug therapy ; SDMA ; Treatment Outcome ; Young Adult</subject><ispartof>Psychiatry research, 2016-04, Vol.238, p.203-210</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-22971b6ce1cb3372b07c2786282d4cb0b777066889e4a0bff964bc52f6b428f63</citedby><cites>FETCH-LOGICAL-c489t-22971b6ce1cb3372b07c2786282d4cb0b777066889e4a0bff964bc52f6b428f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.psychres.2016.02.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27086234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nonaka-Hashida, Satoko</creatorcontrib><creatorcontrib>Sekine, Masae</creatorcontrib><creatorcontrib>Ozeki, Yuji</creatorcontrib><creatorcontrib>Fujii, Kumiko</creatorcontrib><creatorcontrib>Akiyama, Kazufumi</creatorcontrib><creatorcontrib>Shimoda, Kazutaka</creatorcontrib><creatorcontrib>Tsunoda, Makoto</creatorcontrib><creatorcontrib>Katane, Masumi</creatorcontrib><creatorcontrib>Saitoh, Yasuaki</creatorcontrib><creatorcontrib>Miyamoto, Tetsuya</creatorcontrib><creatorcontrib>Homma, Hiroshi</creatorcontrib><title>Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract Plasma concentration of three methylated arginines, endogenous nitric oxide synthase inhibitors, is not studied in schizophrenic patients. The purpose of this study was to determine plasma concentrations of N G - monomethyl- l -arginine ( l -NMMA), N G , N G -dimethyl- l -arginine (ADMA), NG , NG’ -dimethyl- l -arginine (SDMA), and l -arginine in 56 male and 45 female schizophrenic patients undergoing antipsychotic drug treatment versus those of 39 male and 24 female healthy controls. Plasma concentrations of methylated arginines and l -arginine were measured using newly developed high performance liquid chromatography with fluorescence detection which we previously reported. Methylated arginine levels were slightly but significantly higher in schizophrenic patients. l -Arginine levels and the l -arginine/(ADMA+ l -NMMA) ratio were higher in schizophrenic patients than in healthy controls. It is considered that pharmacological treatment of schizophrenic patients may lower methylated arginine levels that are increased by the disease, and increase l -arginine levels, eliciting an improvement in nitric oxide (NO) bioavailability.</description><subject>ADMA</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - blood</subject><subject>Female</subject><subject>Humans</subject><subject>L-arginine</subject><subject>L-NMMA</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>NOS inhibitor</subject><subject>omega-N-Methylarginine - blood</subject><subject>Psychiatry</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - drug therapy</subject><subject>SDMA</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUl2L1TAUDKK419W_sOTRB3tN0t6kfRFl8QsWFNTnkKanba5tUpNUrH_HP-q53l0ffBECIWTODDNzCLnibM8Zl8-P-yVtdoyQ9gLfeybwNPfIjtdKFIqL8j7Z4ceh4KrmF-RRSkfGmOBN85BcCMVqKcpqR359nEyaDbXBW_A5muyCTzT0NCM50BnyuE0mQ0dNHJx3HtIzCr4LA_iwJupdjs7S8MN1QNPm82gSUOdH17ocIoKdp8mO7mdYkNEjdkER1Ep09R3EITg_UOOz--MoZER0cR1ojmDyjMDH5EFvpgRPbu9L8uXN68_X74qbD2_fX7-6KWxVN7kQolG8lRa4bctSiZYpKxT6rEVX2Za1SikmZV03UBnW9n0jq9YeRC_bStS9LC_J0zPvEsO3FVLWs0sWpsl4QKsakxSCS6kqhMoz1MaQUoReL9HNJm6aM30qSB_1XUH6VJBmAk-Dg1e3Gms7Q_d37K4RBLw8AwCdfncQdbKYloXORbBZd8H9X-PFPxR2wuasmb7CBukY1ugxR811wgH96bQmpy3hh5JhiHX5G55gv7M</recordid><startdate>20160430</startdate><enddate>20160430</enddate><creator>Nonaka-Hashida, Satoko</creator><creator>Sekine, Masae</creator><creator>Ozeki, Yuji</creator><creator>Fujii, Kumiko</creator><creator>Akiyama, Kazufumi</creator><creator>Shimoda, Kazutaka</creator><creator>Tsunoda, Makoto</creator><creator>Katane, Masumi</creator><creator>Saitoh, Yasuaki</creator><creator>Miyamoto, Tetsuya</creator><creator>Homma, Hiroshi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160430</creationdate><title>Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment</title><author>Nonaka-Hashida, Satoko ; Sekine, Masae ; Ozeki, Yuji ; Fujii, Kumiko ; Akiyama, Kazufumi ; Shimoda, Kazutaka ; Tsunoda, Makoto ; Katane, Masumi ; Saitoh, Yasuaki ; Miyamoto, Tetsuya ; Homma, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-22971b6ce1cb3372b07c2786282d4cb0b777066889e4a0bff964bc52f6b428f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>ADMA</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - blood</topic><topic>Female</topic><topic>Humans</topic><topic>L-arginine</topic><topic>L-NMMA</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>NOS inhibitor</topic><topic>omega-N-Methylarginine - blood</topic><topic>Psychiatry</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - drug therapy</topic><topic>SDMA</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nonaka-Hashida, Satoko</creatorcontrib><creatorcontrib>Sekine, Masae</creatorcontrib><creatorcontrib>Ozeki, Yuji</creatorcontrib><creatorcontrib>Fujii, Kumiko</creatorcontrib><creatorcontrib>Akiyama, Kazufumi</creatorcontrib><creatorcontrib>Shimoda, Kazutaka</creatorcontrib><creatorcontrib>Tsunoda, Makoto</creatorcontrib><creatorcontrib>Katane, Masumi</creatorcontrib><creatorcontrib>Saitoh, Yasuaki</creatorcontrib><creatorcontrib>Miyamoto, Tetsuya</creatorcontrib><creatorcontrib>Homma, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nonaka-Hashida, Satoko</au><au>Sekine, Masae</au><au>Ozeki, Yuji</au><au>Fujii, Kumiko</au><au>Akiyama, Kazufumi</au><au>Shimoda, Kazutaka</au><au>Tsunoda, Makoto</au><au>Katane, Masumi</au><au>Saitoh, Yasuaki</au><au>Miyamoto, Tetsuya</au><au>Homma, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2016-04-30</date><risdate>2016</risdate><volume>238</volume><spage>203</spage><epage>210</epage><pages>203-210</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><abstract>Abstract Plasma concentration of three methylated arginines, endogenous nitric oxide synthase inhibitors, is not studied in schizophrenic patients. The purpose of this study was to determine plasma concentrations of N G - monomethyl- l -arginine ( l -NMMA), N G , N G -dimethyl- l -arginine (ADMA), NG , NG’ -dimethyl- l -arginine (SDMA), and l -arginine in 56 male and 45 female schizophrenic patients undergoing antipsychotic drug treatment versus those of 39 male and 24 female healthy controls. Plasma concentrations of methylated arginines and l -arginine were measured using newly developed high performance liquid chromatography with fluorescence detection which we previously reported. Methylated arginine levels were slightly but significantly higher in schizophrenic patients. l -Arginine levels and the l -arginine/(ADMA+ l -NMMA) ratio were higher in schizophrenic patients than in healthy controls. It is considered that pharmacological treatment of schizophrenic patients may lower methylated arginine levels that are increased by the disease, and increase l -arginine levels, eliciting an improvement in nitric oxide (NO) bioavailability.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>27086234</pmid><doi>10.1016/j.psychres.2016.02.029</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | ADMA Adult Aged Aged, 80 and over Antipsychotic Agents - therapeutic use Arginine - analogs & derivatives Arginine - blood Female Humans L-arginine L-NMMA Male Middle Aged Nitric Oxide Synthase - antagonists & inhibitors NOS inhibitor omega-N-Methylarginine - blood Psychiatry Schizophrenia Schizophrenia - blood Schizophrenia - drug therapy SDMA Treatment Outcome Young Adult |
| title | Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment |
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