Rapid isolation of peptidic inhibitors of the solute carrier family transporters OATP1B1 and OATP1B3 by cell-based phage display selections

OATP1B1 and OATP1B3 (1B3) are members of organic anion-transporting polypeptides (OATPs), a family of sodium-independent organic anion membrane transporters that contribute to transport of various drugs. To identify peptide inhibitors of OATP1B1, we developed a direct selection system on live cells...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-04, Vol.473 (2), p.370-376
Hauptverfasser:	Arita, Yuko, Allen, Samantha, Chen, Gang, Zhang, Wei, Wang, Ying, Owen, Albert J., Dentinger, Patrick, Sidhu, Sachdev S.
Format:	Artikel
Sprache:	eng
Schlagworte:	5â²CF 6â²CF Amino Acid Sequence ASP bacteriophages Biological Transport - drug effects CDC-NBD Drug Discovery drugs fMTX HEK293 Cells Humans Molecular Sequence Data NTCP OAT1 OAT3 OATP1B1 OATP1B3 OCT1 OCT2 Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - metabolism Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors Organic Anion Transporters, Sodium-Independent - metabolism Organic anion-transporting polypeptides Peptide inhibitor peptide libraries Peptide Library Peptides - chemistry Peptides - pharmacology Phage-display polypeptides Solute Carrier Organic Anion Transporter Family Member 1b1 Solute Carrier Organic Anion Transporter Family Member 1B3 solutes transporters
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