Aspirin curtails the acetaminophen-induced rise in brain norepinephrine levels
We previously showed that acetaminophen administration to rats increases forebrain serotonin levels as a result of the inhibition of liver tryptophan-2,3-dioxygenase (TDO). In this study we determined whether aspirin alone and in combination with acetaminophen could further influence brain serotonin...
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| Veröffentlicht in: | Metabolic brain disease 2004-06, Vol.19 (1-2), p.71-77 |
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| container_title | Metabolic brain disease |
| container_volume | 19 |
| creator | MAHARAJ, Himant MAHARAJ, Deepa S SARAVANAN, Karruppagounder S MOHANAKUMAR, Kochupurackal P DAYA, Santy |
| description | We previously showed that acetaminophen administration to rats increases forebrain serotonin levels as a result of the inhibition of liver tryptophan-2,3-dioxygenase (TDO). In this study we determined whether aspirin alone and in combination with acetaminophen could further influence brain serotonin as well as norepinephrine levels and if so whether the status of the liver TDO activity would be altered. The results show that acetaminophen alone increases brain serotonin as well as norepinephrine levels with a concomitant inhibition of liver TDO activity. In contrast, aspirin did not alter the levels of these monoamines but increased serotonin turnover in the brain while acetaminophen decreased the turnover. When combined with acetaminophen, aspirin overrides the reduced serotonin turnover induced by acetaminophen. This report demonstrates the potential of these agents to alter neurotransmitter levels in the brain. |
| doi_str_mv | 10.1023/B:MEBR.0000027418.33772.8b |
| format | Article |
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In this study we determined whether aspirin alone and in combination with acetaminophen could further influence brain serotonin as well as norepinephrine levels and if so whether the status of the liver TDO activity would be altered. The results show that acetaminophen alone increases brain serotonin as well as norepinephrine levels with a concomitant inhibition of liver TDO activity. In contrast, aspirin did not alter the levels of these monoamines but increased serotonin turnover in the brain while acetaminophen decreased the turnover. When combined with acetaminophen, aspirin overrides the reduced serotonin turnover induced by acetaminophen. This report demonstrates the potential of these agents to alter neurotransmitter levels in the brain.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1023/B:MEBR.0000027418.33772.8b</identifier><identifier>PMID: 15214507</identifier><identifier>CODEN: MBDIEE</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Acetaminophen - pharmacology ; Analgesics, Non-Narcotic - pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Aspirin - pharmacology ; Biological and medical sciences ; Brain Chemistry - drug effects ; Drug Interactions ; Hydroxyindoleacetic Acid - metabolism ; Male ; Medical sciences ; Neurology ; Norepinephrine - metabolism ; Rats ; Rats, Sprague-Dawley ; Serotonin - metabolism</subject><ispartof>Metabolic brain disease, 2004-06, Vol.19 (1-2), p.71-77</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Jun 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-310c7ba08d01911855bd906bf977b3572cbc5d81ee45222cc2b64d1905aaa4f93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15838618$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15214507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAHARAJ, Himant</creatorcontrib><creatorcontrib>MAHARAJ, Deepa S</creatorcontrib><creatorcontrib>SARAVANAN, Karruppagounder S</creatorcontrib><creatorcontrib>MOHANAKUMAR, Kochupurackal P</creatorcontrib><creatorcontrib>DAYA, Santy</creatorcontrib><title>Aspirin curtails the acetaminophen-induced rise in brain norepinephrine levels</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><description>We previously showed that acetaminophen administration to rats increases forebrain serotonin levels as a result of the inhibition of liver tryptophan-2,3-dioxygenase (TDO). 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| subjects | Acetaminophen - pharmacology Analgesics, Non-Narcotic - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aspirin - pharmacology Biological and medical sciences Brain Chemistry - drug effects Drug Interactions Hydroxyindoleacetic Acid - metabolism Male Medical sciences Neurology Norepinephrine - metabolism Rats Rats, Sprague-Dawley Serotonin - metabolism |
| title | Aspirin curtails the acetaminophen-induced rise in brain norepinephrine levels |
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