Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor
Purpose: We examined the effects of the immunosuppressive neuropeptide alpha-melanocyte stimulating hormone (α-MSH) on rat endotoxin-induced uveitis, and to measure the expression of inflammatory cytokines and chemokines with and without the α-MSH treatment over the course of the disease. Methods: W...
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| Veröffentlicht in: | International immunopharmacology 2004-08, Vol.4 (8), p.1059-1066 |
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| creator | Nishida, Tomomi Miyata, Shoji Itoh, Yoshiki Mizuki, Nobuhisa Ohgami, Kazuhiro Shiratori, Kenji Ilieva, Iliyana Bozhidarova Ohno, Shigeaki Taylor, Andrew W |
| description | Purpose: We examined the effects of the immunosuppressive neuropeptide alpha-melanocyte stimulating hormone (α-MSH) on rat endotoxin-induced uveitis, and to measure the expression of inflammatory cytokines and chemokines with and without the α-MSH treatment over the course of the disease.
Methods: We injected Lewis rats once with
Salmonella typhimurium lipopolysaccharide (LPS) to induce uveitis. The rats were given intravenous injections of 250, 500 or 1000 μg of α-MSH. The eyes were examined over the next 24 h for inflammation. Aqueous humor was collected 6, 12 and 24 h after endotoxin injections and the number of infiltrating cells were counted in anterior chamber. In addition, we assayed the concentration of protein, nitric oxide, TNF-α, IL-6, MCP-1 and MIP-2.
Results: Rats injected with α-MSH showed a significant decrease in the number of infiltrating cells in anterior chamber. Moreover, α-MSH-treated rats with endotoxin-induced uveitis (EIU) showed significantly lower concentrations of protein, nitric oxide, proinflammatory cytokines and chemokines in their aqueous humor. Even the early stages of EIU were suppressed by the injection of α-MSH.
Conclusions: Our results demonstrate that the immunosuppressive neuropeptide α-MSH inhibits the early induction events of endotoxin-induced inflammation in the eye; therefore, suppresses the subsequent infiltration of cells and intraocular production of inflammatory cytokines and chemokines in eyes. α-MSH has a possibility of being a therapeutic strategy for anterior uveitis. |
| doi_str_mv | 10.1016/j.intimp.2004.04.011 |
| format | Article |
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Methods: We injected Lewis rats once with
Salmonella typhimurium lipopolysaccharide (LPS) to induce uveitis. The rats were given intravenous injections of 250, 500 or 1000 μg of α-MSH. The eyes were examined over the next 24 h for inflammation. Aqueous humor was collected 6, 12 and 24 h after endotoxin injections and the number of infiltrating cells were counted in anterior chamber. In addition, we assayed the concentration of protein, nitric oxide, TNF-α, IL-6, MCP-1 and MIP-2.
Results: Rats injected with α-MSH showed a significant decrease in the number of infiltrating cells in anterior chamber. Moreover, α-MSH-treated rats with endotoxin-induced uveitis (EIU) showed significantly lower concentrations of protein, nitric oxide, proinflammatory cytokines and chemokines in their aqueous humor. Even the early stages of EIU were suppressed by the injection of α-MSH.
Conclusions: Our results demonstrate that the immunosuppressive neuropeptide α-MSH inhibits the early induction events of endotoxin-induced inflammation in the eye; therefore, suppresses the subsequent infiltration of cells and intraocular production of inflammatory cytokines and chemokines in eyes. α-MSH has a possibility of being a therapeutic strategy for anterior uveitis.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2004.04.011</identifier><identifier>PMID: 15222980</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alpha-melanocyte stimulating hormone ; alpha-MSH - administration & dosage ; alpha-MSH - pharmacokinetics ; alpha-MSH - therapeutic use ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Antineoplastic agents ; Aqueous Humor - metabolism ; Biological and medical sciences ; Cytokine therapy ; Cytokines - metabolism ; Dose-Response Relationship, Drug ; Endotoxin-induced uveitis ; Immunosuppression ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - pharmacokinetics ; Immunosuppressive Agents - therapeutic use ; Lipopolysaccharides ; Male ; Medical sciences ; Neuroimmunomodulation ; Nitric Oxide - metabolism ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Lew ; Salmonella typhimurium ; Time Factors ; Tumors ; Uveitis - chemically induced ; Uveitis - drug therapy</subject><ispartof>International immunopharmacology, 2004-08, Vol.4 (8), p.1059-1066</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-6814363f1387ed1fc943089f993a740c8b9604de9aa654a15fd79c5dee57a2df3</citedby><cites>FETCH-LOGICAL-c419t-6814363f1387ed1fc943089f993a740c8b9604de9aa654a15fd79c5dee57a2df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2004.04.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15893394$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15222980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishida, Tomomi</creatorcontrib><creatorcontrib>Miyata, Shoji</creatorcontrib><creatorcontrib>Itoh, Yoshiki</creatorcontrib><creatorcontrib>Mizuki, Nobuhisa</creatorcontrib><creatorcontrib>Ohgami, Kazuhiro</creatorcontrib><creatorcontrib>Shiratori, Kenji</creatorcontrib><creatorcontrib>Ilieva, Iliyana Bozhidarova</creatorcontrib><creatorcontrib>Ohno, Shigeaki</creatorcontrib><creatorcontrib>Taylor, Andrew W</creatorcontrib><title>Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Purpose: We examined the effects of the immunosuppressive neuropeptide alpha-melanocyte stimulating hormone (α-MSH) on rat endotoxin-induced uveitis, and to measure the expression of inflammatory cytokines and chemokines with and without the α-MSH treatment over the course of the disease.
Methods: We injected Lewis rats once with
Salmonella typhimurium lipopolysaccharide (LPS) to induce uveitis. The rats were given intravenous injections of 250, 500 or 1000 μg of α-MSH. The eyes were examined over the next 24 h for inflammation. Aqueous humor was collected 6, 12 and 24 h after endotoxin injections and the number of infiltrating cells were counted in anterior chamber. In addition, we assayed the concentration of protein, nitric oxide, TNF-α, IL-6, MCP-1 and MIP-2.
Results: Rats injected with α-MSH showed a significant decrease in the number of infiltrating cells in anterior chamber. Moreover, α-MSH-treated rats with endotoxin-induced uveitis (EIU) showed significantly lower concentrations of protein, nitric oxide, proinflammatory cytokines and chemokines in their aqueous humor. Even the early stages of EIU were suppressed by the injection of α-MSH.
Conclusions: Our results demonstrate that the immunosuppressive neuropeptide α-MSH inhibits the early induction events of endotoxin-induced inflammation in the eye; therefore, suppresses the subsequent infiltration of cells and intraocular production of inflammatory cytokines and chemokines in eyes. α-MSH has a possibility of being a therapeutic strategy for anterior uveitis.</description><subject>Alpha-melanocyte stimulating hormone</subject><subject>alpha-MSH - administration & dosage</subject><subject>alpha-MSH - pharmacokinetics</subject><subject>alpha-MSH - therapeutic use</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Antineoplastic agents</subject><subject>Aqueous Humor - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cytokine therapy</subject><subject>Cytokines - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endotoxin-induced uveitis</subject><subject>Immunosuppression</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - pharmacokinetics</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Lipopolysaccharides</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuroimmunomodulation</subject><subject>Nitric Oxide - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Salmonella typhimurium</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>Uveitis - chemically induced</subject><subject>Uveitis - drug therapy</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KVDEQhYMoztj6BiLZ6O62yf1NNsIw-AcDbnQdapJKd5qbpE1yh-nn8UXNpRvUjRBICF-dU1WHkNecbTnj4_vD1oXi_HHbMtZv18P5E3LNxSQaPrHhaX0P49QM0yivyIucD4zV_54_J1d8aNtWCnZNft1UkcYFO4P3UGI6UbQWdck0WgrzcQ-NxxlC1KeCTa6OywzFhR3dx-RjQAo7cCEXmqBQDCaW-OhClTSLRkOXB3TFZQrB0LJHWgWQ6rikjKvDP86ww1CNXaDwc8G4ZLpffEwvyTMLc8ZXl3tDfnz6-P32S3P37fPX25u7RvdclmYUvO_GzvJOTGi41bLvmJBWyg6mnmlxL0fWG5QA49ADH6yZpB4M4jBBa2y3Ie_OuscUq38uyrusca7Tr80oPomWCSYq2J9BnWLOCa06JuchnRRnag1HHdQ5HLWGo9bDeS17c9Ff7j2aP0WXNCrw9gJA1jDbBEG7_BcnZNfVqTbkw5nDuo0Hh0ll7TDUdbtUo1Mmuv938hvJmbQu</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Nishida, Tomomi</creator><creator>Miyata, Shoji</creator><creator>Itoh, Yoshiki</creator><creator>Mizuki, Nobuhisa</creator><creator>Ohgami, Kazuhiro</creator><creator>Shiratori, Kenji</creator><creator>Ilieva, Iliyana Bozhidarova</creator><creator>Ohno, Shigeaki</creator><creator>Taylor, Andrew W</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20040801</creationdate><title>Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor</title><author>Nishida, Tomomi ; Miyata, Shoji ; Itoh, Yoshiki ; Mizuki, Nobuhisa ; Ohgami, Kazuhiro ; Shiratori, Kenji ; Ilieva, Iliyana Bozhidarova ; Ohno, Shigeaki ; Taylor, Andrew W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-6814363f1387ed1fc943089f993a740c8b9604de9aa654a15fd79c5dee57a2df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alpha-melanocyte stimulating hormone</topic><topic>alpha-MSH - administration & dosage</topic><topic>alpha-MSH - pharmacokinetics</topic><topic>alpha-MSH - therapeutic use</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Antineoplastic agents</topic><topic>Aqueous Humor - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cytokine therapy</topic><topic>Cytokines - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endotoxin-induced uveitis</topic><topic>Immunosuppression</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Immunosuppressive Agents - pharmacokinetics</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Lipopolysaccharides</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuroimmunomodulation</topic><topic>Nitric Oxide - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Salmonella typhimurium</topic><topic>Time Factors</topic><topic>Tumors</topic><topic>Uveitis - chemically induced</topic><topic>Uveitis - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishida, Tomomi</creatorcontrib><creatorcontrib>Miyata, Shoji</creatorcontrib><creatorcontrib>Itoh, Yoshiki</creatorcontrib><creatorcontrib>Mizuki, Nobuhisa</creatorcontrib><creatorcontrib>Ohgami, Kazuhiro</creatorcontrib><creatorcontrib>Shiratori, Kenji</creatorcontrib><creatorcontrib>Ilieva, Iliyana Bozhidarova</creatorcontrib><creatorcontrib>Ohno, Shigeaki</creatorcontrib><creatorcontrib>Taylor, Andrew W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishida, Tomomi</au><au>Miyata, Shoji</au><au>Itoh, Yoshiki</au><au>Mizuki, Nobuhisa</au><au>Ohgami, Kazuhiro</au><au>Shiratori, Kenji</au><au>Ilieva, Iliyana Bozhidarova</au><au>Ohno, Shigeaki</au><au>Taylor, Andrew W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>4</volume><issue>8</issue><spage>1059</spage><epage>1066</epage><pages>1059-1066</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Purpose: We examined the effects of the immunosuppressive neuropeptide alpha-melanocyte stimulating hormone (α-MSH) on rat endotoxin-induced uveitis, and to measure the expression of inflammatory cytokines and chemokines with and without the α-MSH treatment over the course of the disease.
Methods: We injected Lewis rats once with
Salmonella typhimurium lipopolysaccharide (LPS) to induce uveitis. The rats were given intravenous injections of 250, 500 or 1000 μg of α-MSH. The eyes were examined over the next 24 h for inflammation. Aqueous humor was collected 6, 12 and 24 h after endotoxin injections and the number of infiltrating cells were counted in anterior chamber. In addition, we assayed the concentration of protein, nitric oxide, TNF-α, IL-6, MCP-1 and MIP-2.
Results: Rats injected with α-MSH showed a significant decrease in the number of infiltrating cells in anterior chamber. Moreover, α-MSH-treated rats with endotoxin-induced uveitis (EIU) showed significantly lower concentrations of protein, nitric oxide, proinflammatory cytokines and chemokines in their aqueous humor. Even the early stages of EIU were suppressed by the injection of α-MSH.
Conclusions: Our results demonstrate that the immunosuppressive neuropeptide α-MSH inhibits the early induction events of endotoxin-induced inflammation in the eye; therefore, suppresses the subsequent infiltration of cells and intraocular production of inflammatory cytokines and chemokines in eyes. α-MSH has a possibility of being a therapeutic strategy for anterior uveitis.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15222980</pmid><doi>10.1016/j.intimp.2004.04.011</doi><tpages>8</tpages></addata></record> |
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| subjects | Alpha-melanocyte stimulating hormone alpha-MSH - administration & dosage alpha-MSH - pharmacokinetics alpha-MSH - therapeutic use Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antineoplastic agents Aqueous Humor - metabolism Biological and medical sciences Cytokine therapy Cytokines - metabolism Dose-Response Relationship, Drug Endotoxin-induced uveitis Immunosuppression Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - therapeutic use Lipopolysaccharides Male Medical sciences Neuroimmunomodulation Nitric Oxide - metabolism Pharmacology. Drug treatments Rats Rats, Inbred Lew Salmonella typhimurium Time Factors Tumors Uveitis - chemically induced Uveitis - drug therapy |
| title | Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor |
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