Aryl Hydrocarbon Receptor-Deficient Mice Generate Normal Immune Responses to Model Antigens and Are Resistant to TCDD-Induced Immune Suppression

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the toxic effects induced by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a high-affinity AhR ligand and a potent immunotoxicant. AhR-deficient mice have been constructed, and there are re...

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Veröffentlicht in:	Toxicology and applied pharmacology 2001-03, Vol.171 (3), p.157-164
Hauptverfasser:	Vorderstrasse, Beth A., Steppan, Linda B., Silverstone, Allen E., Kerkvliet, Nancy I.
Format:	Artikel
Sprache:	eng
Schlagworte:	AAh receptors AHR AHR-deficient mice Animals Antibodies, Neoplasm - biosynthesis Antibodies, Neoplasm - immunology Antibody Formation - genetics Antigens, Neoplasm - immunology aryl hydrocarbon receptor Biological and medical sciences cell-mediated immunity Chemical and industrial products toxicology. Toxic occupational diseases Drug Resistance Erythrocytes - immunology Flow Cytometry humoral immunity Immunosuppressive Agents - pharmacology Medical sciences Polychlorinated Dibenzodioxins - pharmacology Receptors, Aryl Hydrocarbon - deficiency Receptors, Aryl Hydrocarbon - genetics Sheep Spleen - cytology T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology TCDD Toxicology Tumor Cells, Cultured Various organic compounds
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