Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin
The aim of this study was to evaluate the physical–chemical properties, in vivo biocompatibility and antimicrobial activity of bioactive glasses (BG) used as a controlled release device for tetracycline hydrochloride and an inclusion complex formed by tetracycline and β-cyclodextrin at 1:1 molar rat...
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| Veröffentlicht in: | Biomaterials 2004, Vol.25 (2), p.327-333 |
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| creator | Domingues, Z.R. Cortés, M.E. Gomes, T.A. Diniz, H.F. Freitas, C.S. Gomes, J.B. Faria, A.M.C. Sinisterra, R.D |
| description | The aim of this study was to evaluate the physical–chemical properties, in vivo biocompatibility and antimicrobial activity of bioactive glasses (BG) used as a controlled release device for tetracycline hydrochloride and an inclusion complex formed by tetracycline and
β-cyclodextrin at 1:1
molar ratio. The BG as well as their compounds loaded with tetracycline (BT) and tetracycline:
β-cyclodextrin (BTC) were characterized by FTIR spectroscopy, X-ray powder diffraction, differential scanning calorimetry and by scanning electron microscopy and energy dispersive spectroscopy. The in vivo test was carried out with female mice split into three groups treated with bioactive glass either without drugs, or associated with tetracycline, or with tetracycline:
β-cyclodextrin by subcutaneous implantation. The histological examination of tissue at the site of implantation showed moderate inflammatory reactions in all groups after 72
h. The bacterial effect was tested on
A. actinomycetemcomitans suspended in BHI broth, with or without bioactive particles. A considerable bacteriostatic activity was found with BT and BTC glasses, as compared to plain glass. The presence of cyclodextrin was important to slow down the release of tetracycline for a long period of time and it was verified that the presence of tetracycline or its inclusion complex, tetracycline:
β-cyclodextrin, did not affect the bioactivity of the glass. |
| doi_str_mv | 10.1016/S0142-9612(03)00524-6 |
| format | Article |
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β-cyclodextrin at 1:1
molar ratio. The BG as well as their compounds loaded with tetracycline (BT) and tetracycline:
β-cyclodextrin (BTC) were characterized by FTIR spectroscopy, X-ray powder diffraction, differential scanning calorimetry and by scanning electron microscopy and energy dispersive spectroscopy. The in vivo test was carried out with female mice split into three groups treated with bioactive glass either without drugs, or associated with tetracycline, or with tetracycline:
β-cyclodextrin by subcutaneous implantation. The histological examination of tissue at the site of implantation showed moderate inflammatory reactions in all groups after 72
h. The bacterial effect was tested on
A. actinomycetemcomitans suspended in BHI broth, with or without bioactive particles. A considerable bacteriostatic activity was found with BT and BTC glasses, as compared to plain glass. The presence of cyclodextrin was important to slow down the release of tetracycline for a long period of time and it was verified that the presence of tetracycline or its inclusion complex, tetracycline:
β-cyclodextrin, did not affect the bioactivity of the glass.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(03)00524-6</identifier><identifier>PMID: 14585720</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; beta-Cyclodextrins ; Bioactive glass ; Biocompatibility ; Biocompatible Materials - chemistry ; Cyclodextrins - administration & dosage ; Cyclodextrins - chemistry ; Cyclodextrins - pharmacokinetics ; Drug Delivery Systems ; Glass - chemistry ; Hot Temperature ; Mice ; Spectroscopy, Fourier Transform Infrared ; Tetracycline - administration & dosage ; Tetracycline - chemistry ; Tetracycline - pharmacokinetics ; Tetracycline hydrochloride ; β-cyclodextrin</subject><ispartof>Biomaterials, 2004, Vol.25 (2), p.327-333</ispartof><rights>2003 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-e7de86c4963d3295c2652cf8fda8322e081c3b5fbe6e9c335ba639cf51ea3f183</citedby><cites>FETCH-LOGICAL-c392t-e7de86c4963d3295c2652cf8fda8322e081c3b5fbe6e9c335ba639cf51ea3f183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0142-9612(03)00524-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14585720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domingues, Z.R.</creatorcontrib><creatorcontrib>Cortés, M.E.</creatorcontrib><creatorcontrib>Gomes, T.A.</creatorcontrib><creatorcontrib>Diniz, H.F.</creatorcontrib><creatorcontrib>Freitas, C.S.</creatorcontrib><creatorcontrib>Gomes, J.B.</creatorcontrib><creatorcontrib>Faria, A.M.C.</creatorcontrib><creatorcontrib>Sinisterra, R.D</creatorcontrib><title>Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>The aim of this study was to evaluate the physical–chemical properties, in vivo biocompatibility and antimicrobial activity of bioactive glasses (BG) used as a controlled release device for tetracycline hydrochloride and an inclusion complex formed by tetracycline and
β-cyclodextrin at 1:1
molar ratio. The BG as well as their compounds loaded with tetracycline (BT) and tetracycline:
β-cyclodextrin (BTC) were characterized by FTIR spectroscopy, X-ray powder diffraction, differential scanning calorimetry and by scanning electron microscopy and energy dispersive spectroscopy. The in vivo test was carried out with female mice split into three groups treated with bioactive glass either without drugs, or associated with tetracycline, or with tetracycline:
β-cyclodextrin by subcutaneous implantation. The histological examination of tissue at the site of implantation showed moderate inflammatory reactions in all groups after 72
h. The bacterial effect was tested on
A. actinomycetemcomitans suspended in BHI broth, with or without bioactive particles. A considerable bacteriostatic activity was found with BT and BTC glasses, as compared to plain glass. The presence of cyclodextrin was important to slow down the release of tetracycline for a long period of time and it was verified that the presence of tetracycline or its inclusion complex, tetracycline:
β-cyclodextrin, did not affect the bioactivity of the glass.</description><subject>Animals</subject><subject>beta-Cyclodextrins</subject><subject>Bioactive glass</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - chemistry</subject><subject>Cyclodextrins - administration & dosage</subject><subject>Cyclodextrins - chemistry</subject><subject>Cyclodextrins - pharmacokinetics</subject><subject>Drug Delivery Systems</subject><subject>Glass - chemistry</subject><subject>Hot Temperature</subject><subject>Mice</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Tetracycline - administration & dosage</subject><subject>Tetracycline - chemistry</subject><subject>Tetracycline - pharmacokinetics</subject><subject>Tetracycline hydrochloride</subject><subject>β-cyclodextrin</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotlYfQclKdDGayyTNrESLNxBcqOuQJmdqynSmJmm1r-WD-ExOLyi4EQIhf75zDudD6JCSM0qoPH8iNGdZISk7IfyUEMHyTG6hLlV9lYmCiG3U_UE6aC_GMWnfJGe7qENzoUSfkS4aX_nG2OTngEeViRGb9mAXZiPsoGrjsMBxERNMcFPiBCkYu7CVrwGb2v0JYmysNwkcfvfpFX99ZsuvxsFHCr7eRzulqSIcbO4eerm5fh7cZQ-Pt_eDy4fM8oKlDPoOlLR5IbnjrBCWScFsqUpnFGcMiKKWD0U5BAmF5VwMjeSFLQUFw0uqeA8dr_tOQ_M2g5j0xEcLVWVqaGZR076iitCiBcUatKGJMUCpp8FPTFhoSvRSsl5J1kuDmnC9kqxlW3e0GTAbTsD9Vm2stsDFGoB2zbmHoKP1UFtwPoBN2jX-nxHf57iOvQ</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Domingues, Z.R.</creator><creator>Cortés, M.E.</creator><creator>Gomes, T.A.</creator><creator>Diniz, H.F.</creator><creator>Freitas, C.S.</creator><creator>Gomes, J.B.</creator><creator>Faria, A.M.C.</creator><creator>Sinisterra, R.D</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2004</creationdate><title>Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin</title><author>Domingues, Z.R. ; Cortés, M.E. ; Gomes, T.A. ; Diniz, H.F. ; Freitas, C.S. ; Gomes, J.B. ; Faria, A.M.C. ; Sinisterra, R.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-e7de86c4963d3295c2652cf8fda8322e081c3b5fbe6e9c335ba639cf51ea3f183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>beta-Cyclodextrins</topic><topic>Bioactive glass</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials - chemistry</topic><topic>Cyclodextrins - administration & dosage</topic><topic>Cyclodextrins - chemistry</topic><topic>Cyclodextrins - pharmacokinetics</topic><topic>Drug Delivery Systems</topic><topic>Glass - chemistry</topic><topic>Hot Temperature</topic><topic>Mice</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Tetracycline - administration & dosage</topic><topic>Tetracycline - chemistry</topic><topic>Tetracycline - pharmacokinetics</topic><topic>Tetracycline hydrochloride</topic><topic>β-cyclodextrin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Domingues, Z.R.</creatorcontrib><creatorcontrib>Cortés, M.E.</creatorcontrib><creatorcontrib>Gomes, T.A.</creatorcontrib><creatorcontrib>Diniz, H.F.</creatorcontrib><creatorcontrib>Freitas, C.S.</creatorcontrib><creatorcontrib>Gomes, J.B.</creatorcontrib><creatorcontrib>Faria, A.M.C.</creatorcontrib><creatorcontrib>Sinisterra, R.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Domingues, Z.R.</au><au>Cortés, M.E.</au><au>Gomes, T.A.</au><au>Diniz, H.F.</au><au>Freitas, C.S.</au><au>Gomes, J.B.</au><au>Faria, A.M.C.</au><au>Sinisterra, R.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2004</date><risdate>2004</risdate><volume>25</volume><issue>2</issue><spage>327</spage><epage>333</epage><pages>327-333</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>The aim of this study was to evaluate the physical–chemical properties, in vivo biocompatibility and antimicrobial activity of bioactive glasses (BG) used as a controlled release device for tetracycline hydrochloride and an inclusion complex formed by tetracycline and
β-cyclodextrin at 1:1
molar ratio. The BG as well as their compounds loaded with tetracycline (BT) and tetracycline:
β-cyclodextrin (BTC) were characterized by FTIR spectroscopy, X-ray powder diffraction, differential scanning calorimetry and by scanning electron microscopy and energy dispersive spectroscopy. The in vivo test was carried out with female mice split into three groups treated with bioactive glass either without drugs, or associated with tetracycline, or with tetracycline:
β-cyclodextrin by subcutaneous implantation. The histological examination of tissue at the site of implantation showed moderate inflammatory reactions in all groups after 72
h. The bacterial effect was tested on
A. actinomycetemcomitans suspended in BHI broth, with or without bioactive particles. A considerable bacteriostatic activity was found with BT and BTC glasses, as compared to plain glass. The presence of cyclodextrin was important to slow down the release of tetracycline for a long period of time and it was verified that the presence of tetracycline or its inclusion complex, tetracycline:
β-cyclodextrin, did not affect the bioactivity of the glass.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>14585720</pmid><doi>10.1016/S0142-9612(03)00524-6</doi><tpages>7</tpages></addata></record> |
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| issn | 0142-9612 1878-5905 |
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| subjects | Animals beta-Cyclodextrins Bioactive glass Biocompatibility Biocompatible Materials - chemistry Cyclodextrins - administration & dosage Cyclodextrins - chemistry Cyclodextrins - pharmacokinetics Drug Delivery Systems Glass - chemistry Hot Temperature Mice Spectroscopy, Fourier Transform Infrared Tetracycline - administration & dosage Tetracycline - chemistry Tetracycline - pharmacokinetics Tetracycline hydrochloride β-cyclodextrin |
| title | Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin |
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